Literature DB >> 16246555

Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors.

Xiaoan Wen1, Pu Zhang, Jun Liu, Luyong Zhang, Xiaoming Wu, Peizhou Ni, Hongbin Sun.   

Abstract

The synthesis of a series of maslinic acid derivatives is described and their effect on rabbit muscle glycogen phosphorylase a evaluated. Within this series of compounds, 15 (IC(50)=7 microM) is the most potent GPa inhibitor. SAR of the maslinic acid derivatives are discussed.

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Year:  2005        PMID： 16246555     DOI： 10.1016/j.bmcl.2005.10.014

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Maslinic acid induced apoptosis in bladder cancer cells through activating p38 MAPK signaling pathway.

Authors:  Shilong Zhang; Degang Ding; Xiangsheng Zhang; Lei Shan; Zhonghua Liu
Journal:  Mol Cell Biochem       Date:  2014-04-01       Impact factor: 3.396

2.  Efficient synthesis and biological evaluation of epiceanothic acid and related compounds.

Authors:  Pu Zhang; Li Xu; Keduo Qian; Jun Liu; Luyong Zhang; Kuo-Hsiung Lee; Hongbin Sun
Journal:  Bioorg Med Chem Lett       Date:  2010-11-05       Impact factor: 2.823

3.  Amoebicidal Activity of Caffeine and Maslinic Acid by the Induction of Programmed Cell Death in Acanthamoeba.

Authors:  Carmen M Martín-Navarro; Atteneri López-Arencibia; Ines Sifaoui; María Reyes-Batlle; Emilie Fouque; Antonio Osuna; Basilio Valladares; José E Piñero; Yann Héchard; Sutherland K Maciver; Jacob Lorenzo-Morales
Journal:  Antimicrob Agents Chemother       Date:  2017-05-24       Impact factor: 5.191

4.  Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages.

Authors:  Carlos Moneriz; Patricia Marín-García; Andrés García-Granados; José M Bautista; Amalia Diez; Antonio Puyet
Journal:  Malar J       Date:  2011-04-10       Impact factor: 2.979

5.  Carb-oxy-methyl ursolate monohydrate.

Authors:  Yan Zhong; Zhaohui Dai; Yanbo Teng; Bin Wu; Jianping Zhou
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-01-15

6.  Combination therapy with oleanolic acid and metformin as a synergistic treatment for diabetes.

Authors:  Xue Wang; Yupeng Chen; Daoud Abdelkader; Waseem Hassan; Hongbin Sun; Jun Liu
Journal:  J Diabetes Res       Date:  2015-02-18       Impact factor: 4.011

7.  Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate.

Authors:  Raya Soltane; Amani Chrouda; Ahmed Mostafa; Ahmed A Al-Karmalawy; Karim Chouaïb; Abdelwaheb Dhahri; Rami Adel Pashameah; Ahlam Alasiri; Omnia Kutkat; Mahmoud Shehata; Hichem Ben Jannet; Jawhar Gharbi; Mohamed A Ali
Journal:  Pathogens       Date:  2021-05-19

8.  Maslinic Acid, a Triterpene from Olive, Affects the Antioxidant and Mitochondrial Status of B16F10 Melanoma Cells Grown under Stressful Conditions.

Authors:  Khalida Mokhtari; Eva E Rufino-Palomares; Amalia Pérez-Jiménez; Fernando J Reyes-Zurita; Celeny Figuera; Leticia García-Salguero; Pedro P Medina; Juan Peragón; José A Lupiáñez
Journal:  Evid Based Complement Alternat Med       Date:  2015-07-07       Impact factor: 2.629

Review 9.  The role of triterpenes in the management of diabetes mellitus and its complications.

Authors:  J Nazaruk; M Borzym-Kluczyk
Journal:  Phytochem Rev       Date:  2014-06-24       Impact factor: 5.374

10.  Maslinic acid activates renal AMPK/SIRT1 signaling pathway and protects against diabetic nephropathy in mice.

Authors:  Huijuan Gao; Hong Wu
Journal:  BMC Endocr Disord       Date:  2022-01-18       Impact factor: 2.763
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