Literature DB >> 16246550

PET imaging and optical imaging with D-luciferin [11C]methyl ester and D-luciferin [11C]methyl ether of luciferase gene expression in tumor xenografts of living mice.

Ji-Quan Wang1, Karen E Pollok, Shanbao Cai, Keith M Stantz, Gary D Hutchins, Qi-Huang Zheng.   

Abstract

New carbon-11 labeled D-luciferin analogs D-luciferin [(11)C]methyl ester ([(11)C]LMEster, [(11)C]1) and D-luciferin [(11)C]methyl ether ([(11)C]LMEther, [(11)C]2) were synthesized in 25-55% radiochemical yield. PET studies with [(11)C]LMEster and [(11)C]LMEther demonstrate a lower retention of the C-11 label at 45 min post-injection in luciferase expression tumor. Optical imaging with unlabeled substrate D-luciferin and radiotracers [(11)C]LMEster and [(11)C]LMEther gave tumor luciferase images within a few minutes of photon counting.

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Year:  2005        PMID： 16246550     DOI： 10.1016/j.bmcl.2005.09.082

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Imaging gene expression in live cells and tissues.

Authors:  Hao Hong; Yunan Yang; Weibo Cai
Journal:  Cold Spring Harb Protoc       Date:  2011-04-01

2.  Uptake kinetics and biodistribution of 14C-D-luciferin--a radiolabeled substrate for the firefly luciferase catalyzed bioluminescence reaction: impact on bioluminescence based reporter gene imaging.

Authors:  Frank Berger; Ramasamy Paulmurugan; Srabani Bhaumik; Sanjiv Sam Gambhir
Journal:  Eur J Nucl Med Mol Imaging       Date:  2008-07-26       Impact factor: 9.236

3.  Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation.

Authors:  H Zhang; D H Fagan; X Zeng; K T Freeman; D Sachdev; D Yee
Journal:  Oncogene       Date:  2010-02-15       Impact factor: 9.867

4.  Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo.

Authors:  Yan Li; Shi Chen; Jin Yuan; Yanzhu Yang; Jingling Li; Jin Ma; Xiaohua Wu; Marcel Freund; Karen Pollok; Helmut Hanenberg; W Scott Goebel; Feng-Chun Yang
Journal:  Blood       Date:  2009-01-07       Impact factor: 22.113

5.  A dual-color far-red to near-infrared firefly luciferin analogue designed for multiparametric bioluminescence imaging.

Authors:  Amit P Jathoul; Helen Grounds; James C Anderson; Martin A Pule
Journal:  Angew Chem Int Ed Engl       Date:  2014-09-29       Impact factor: 15.336

6.  Bioluminescent imaging of drug efflux at the blood-brain barrier mediated by the transporter ABCG2.

Authors:  Joshua Bakhsheshian; Bih-Rong Wei; Ki-Eun Chang; Suneet Shukla; Suresh V Ambudkar; R Mark Simpson; Michael M Gottesman; Matthew D Hall
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-02       Impact factor: 11.205
  6 in total

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