Literature DB >> 16246156

The regulation of cell migration by PTEN.

N R Leslie1, X Yang, C P Downes, C J Weijer.   

Abstract

In vertebrates, the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) regulates many cellular processes through its PtdIns(3,4,5)P3 lipid phosphatase activity, antagonizing PI3K (phosphoinositide 3-kinase) signalling. Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN in the regulation of cell migration.

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Year:  2005        PMID： 16246156     DOI： 10.1042/BST20051507

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  21 in total

1.  PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migration.

Authors:  Cosmin Mihai; Shengying Bao; Ju-Ping Lai; Samir N Ghadiali; Daren L Knoell
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2011-10-28       Impact factor: 5.464

2.  Doubles game: Src-Stat3 versus p53-PTEN in cellular migration and invasion.

Authors:  Utpal K Mukhopadhyay; Patrick Mooney; Lilly Jia; Robert Eves; Leda Raptis; Alan S Mak
Journal:  Mol Cell Biol       Date:  2010-08-23       Impact factor: 4.272

3.  PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition.

Authors:  Z Meng; L-F Jia; Y-H Gan
Journal:  Oncogene       Date:  2015-08-17       Impact factor: 9.867

4.  Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane.

Authors:  Francisca Vazquez; Satomi Matsuoka; William R Sellers; Toshio Yanagida; Masahiro Ueda; Peter N Devreotes
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-28       Impact factor: 11.205

5.  PTEN regulates lung endodermal morphogenesis through MEK/ERK pathway.

Authors:  Yiming Xing; Runming Wang; Changgong Li; Parviz Minoo
Journal:  Dev Biol       Date:  2015-10-13       Impact factor: 3.582

6.  miR-29b regulates migration of human breast cancer cells.

Authors:  Chen Wang; Zhen Bian; Da Wei; Jian-guo Zhang
Journal:  Mol Cell Biochem       Date:  2011-02-26       Impact factor: 3.396

7.  MicroRNA-203 Inhibits Long Noncoding RNA HOTAIR and Regulates Tumorigenesis through Epithelial-to-mesenchymal Transition Pathway in Renal Cell Carcinoma.

Authors:  Pritha Dasgupta; Priyanka Kulkarni; Shahana Majid; Varahram Shahryari; Yutaka Hashimoto; Nadeem S Bhat; Marisa Shiina; Guoren Deng; Sharanjot Saini; Z Laura Tabatabai; Soichiro Yamamura; Yuichiro Tanaka; Rajvir Dahiya
Journal:  Mol Cancer Ther       Date:  2018-02-13       Impact factor: 6.261

Review 8.  Compartmentalization of redox signaling through NADPH oxidase-derived ROS.

Authors:  Masuko Ushio-Fukai
Journal:  Antioxid Redox Signal       Date:  2009-06       Impact factor: 8.401

9.  Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia.

Authors:  Yitang Li; Yonghui Jia; Muriel Pichavant; Fabien Loison; Bara Sarraj; Anongnard Kasorn; Jian You; Bryanne E Robson; Dale T Umetsu; Joseph P Mizgerd; Keqiang Ye; Hongbo R Luo
Journal:  Blood       Date:  2009-03-13       Impact factor: 22.113

10.  Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia.

Authors:  Ian J Frew; Andrea Minola; Strahil Georgiev; Manuela Hitz; Holger Moch; Stéphane Richard; Alexander O Vortmeyer; Wilhelm Krek
Journal:  Mol Cell Biol       Date:  2008-05-12       Impact factor: 4.272
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