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Literature DB >> 16246105

Genetic, biochemical and structural approaches to talin function.

Abstract

The cytoskeletal protein talin plays a key role in coupling the integrin family of cell adhesion molecules to the actin cytoskeleton. In this paper I present a brief review on talin and summarize our recent studies, in which we have taken both genetic and structural approaches to further elucidate the function of the protein.

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Year: 2005 PMID： 16246105 DOI： 10.1042/BST20051308

Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407

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Cited

18 in total

1. An essential role for talin during alpha(M)beta(2)-mediated phagocytosis.

Authors: Jenson Lim; Agnès Wiedemann; George Tzircotis; Susan J Monkley; David R Critchley; Emmanuelle Caron
Journal: Mol Biol Cell Date: 2007-01-03 Impact factor: 4.138

Review 2. Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases.

Authors: Yuntao S Mao; Helen L Yin
Journal: Pflugers Arch Date: 2007-05-23 Impact factor: 3.657

3. Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions.

Authors: Mirko Himmel; Anett Ritter; Sven Rothemund; Björg V Pauling; Klemens Rottner; Alexandre R Gingras; Wolfgang H Ziegler
Journal: J Biol Chem Date: 2009-03-11 Impact factor: 5.157

Review 4. Focal adhesion: a focal point in current cell biology and molecular medicine.

Authors: Chuanyue Wu
Journal: Cell Adh Migr Date: 2007-01-27 Impact factor: 3.405

Review 5. Kindlins: essential regulators of integrin signalling and cell-matrix adhesion.

Authors: Hannu Larjava; Edward F Plow; Chuanyue Wu
Journal: EMBO Rep Date: 2008-11-07 Impact factor: 8.807

6. Integrin alphaIIbbeta3 activation in Chinese hamster ovary cells and platelets increases clustering rather than affinity.

Authors: Thomas A Bunch
Journal: J Biol Chem Date: 2009-11-16 Impact factor: 5.157

Genetic, biochemical and structural approaches to talin function.

1. An essential role for talin during alpha(M)beta(2)-mediated phagocytosis.

Review 2. Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases.

3. Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions.

Review 4. Focal adhesion: a focal point in current cell biology and molecular medicine.

Review 5. Kindlins: essential regulators of integrin signalling and cell-matrix adhesion.

6. Integrin alphaIIbbeta3 activation in Chinese hamster ovary cells and platelets increases clustering rather than affinity.

Review 7. The final steps of integrin activation: the end game.

8. Spatial Segregation of Phosphatidylinositol 4,5-Bisphosphate (PIP(2)) Signaling in Immune Cell Functions.

Review 9. Control of cell adhesion dynamics by Rap1 signaling.

Review 10. Single-cell imaging of mechanotransduction in endothelial cells.