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Literature DB >> 1624608

Parathyroid hormone related protein in hypercalcaemia of Hodgkin's disease.

J Bolo-Deoku¹, S Basu, S Lakhani, F Dunne, W A Ratcliffe, M Clarke, J L Barron.

Abstract

The role of parathyroid hormone related protein (PTHRP) as a humoral mediator of hypercalcaemia was investigated in a patient with lymphocyte depleted Hodgkin's disease during an episode of hypercalcaemia, using an immunohistochemical staining technique for PTHRP on the tumour tissue and an immunoradiometric (IRMA) assay for PTHRP1-86 on the patient's plasma. The plasma PTHRP was less than 0.23 pmol/l in the range found in normocalcaemic controls, and the immunohistochemical staining was not positive for protein. PTHRP did not have a role in the pathogenesis of hypercalcaemia in this patient.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1992 PMID： 1624608 PMCID： PMC495236 DOI： 10.1136/jcp.45.6.541

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

12 in total

1. Hodgkin's disease presenting with hypercalcaemia.

Authors: R D Ellis; P R Beck; B K Mondal
Journal: J Clin Pathol Date: 1989-11 Impact factor: 3.411

2. Recurrent hypercalcemia and elevated 1,25-dihydroxyvitamin D levels in Hodgkin's disease.

Authors: R J Mercier; J M Thompson; G S Harman; G L Messerschmidt
Journal: Am J Med Date: 1988-01 Impact factor: 4.965

3. Hypercalcaemia in Hodgkin's disease without hyperparathyroidism or skeletal metastases.

Authors: K M Mayne; C Bunch
Journal: J Clin Pathol Date: 1989-02 Impact factor: 3.411

4. Hypercalcemia, Hodgkin's disease, and calcitriol.

Authors: M A Needle; B Chandra
Journal: Ann Intern Med Date: 1984-06 Impact factor: 25.391

5. Parathyroid hormone-related protein of malignancy: immunohistochemical and biochemical studies in normocalcaemic and hypercalcaemic patients with cancer.

Authors: S H Ralston; J Danks; J Hayman; W D Fraser; C S Stewart; T J Martin
Journal: J Clin Pathol Date: 1991-06 Impact factor: 3.411

Review 6. Humoral hypercalcemia in Hodgkin's disease. Clinical and laboratory evaluation.

Authors: J O Jacobson; F R Bringhurst; N L Harris; S A Weitzman; A C Aisenberg
Journal: Cancer Date: 1989-03-01 Impact factor: 6.860

7. Parathyroid hormone related protein and hypercalcaemia in breast cancer.

Authors: N J Bundred; W A Ratcliffe; R A Walker; S Coley; J M Morrison; J G Ratcliffe
Journal: BMJ Date: 1991-12-14

8. Parathyroid hormone-related protein: immunohistochemical localization in cancers and in normal skin.

Authors: J A Danks; P R Ebeling; J Hayman; S T Chou; J M Moseley; J Dunlop; B E Kemp; T J Martin
Journal: J Bone Miner Res Date: 1989-04 Impact factor: 6.741

Review 9. Hypercalcemia and vitamin D metabolism in Hodgkin's disease. Is there an underlying immunoregulatory relationship?

Authors: J W Rieke; S S Donaldson; S J Horning
Journal: Cancer Date: 1989-05-01 Impact factor: 6.860

10. Immunocytochemical demonstration of PTHrP protein in neoplastic tissue of HTLV-1 positive human adult T cell leukaemia/lymphoma: implications for the mechanism of hypercalcaemia.

Authors: J M Moseley; J A Danks; V Grill; T A Lister; M A Horton
Journal: Br J Cancer Date: 1991-10 Impact factor: 7.640

3 in total