Literature DB >> 16245070

Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation.

T Canli1, E Congdon, L Gutknecht, R T Constable, K P Lesch.   

Abstract

The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.

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Year:  2005        PMID： 16245070     DOI： 10.1007/s00702-005-0391-4

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  17 in total

1.  Amygdala response to happy faces as a function of extraversion.

Authors:  Turhan Canli; Heidi Sivers; Susan L Whitfield; Ian H Gotlib; John D E Gabrieli
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2.  Amygdalar activation associated with positive and negative facial expressions.

Authors:  Tony T Yang; Vinod Menon; Stephan Eliez; Christine Blasey; Christopher D White; Amy J Reid; Ian H Gotlib; Allan L Reiss
Journal:  Neuroreport       Date:  2002-10-07       Impact factor: 1.837

3.  Support for the involvement of TPH2 gene in affective disorders.

Authors:  M Harvey; E Shink; M Tremblay; B Gagné; C Raymond; M Labbé; D J Walther; M Bader; N Barden
Journal:  Mol Psychiatry       Date:  2004-11       Impact factor: 15.992

4.  Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.

Authors:  S Walitza; T J Renner; A Dempfle; K Konrad; Ch Wewetzer; A Halbach; B Herpertz-Dahlmann; H Remschmidt; J Smidt; M Linder; L Flierl; U Knölker; S Friedel; H Schäfer; C Gross; J Hebebrand; A Warnke; K P Lesch
Journal:  Mol Psychiatry       Date:  2005-12       Impact factor: 15.992

5.  5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression.

Authors:  Lukas Pezawas; Andreas Meyer-Lindenberg; Emily M Drabant; Beth A Verchinski; Karen E Munoz; Bhaskar S Kolachana; Michael F Egan; Venkata S Mattay; Ahmad R Hariri; Daniel R Weinberger
Journal:  Nat Neurosci       Date:  2005-05-08       Impact factor: 24.884

6.  Amygdala reactivity to emotional faces predicts improvement in major depression.

Authors:  Turhan Canli; Rebecca E Cooney; Philippe Goldin; Maulik Shah; Heidi Sivers; Moriah E Thomason; Susan Whitfield-Gabrieli; John D E Gabrieli; Ian H Gotlib
Journal:  Neuroreport       Date:  2005-08-22       Impact factor: 1.837

7.  A susceptibility gene for affective disorders and the response of the human amygdala.

Authors:  Ahmad R Hariri; Emily M Drabant; Karen E Munoz; Bhaskar S Kolachana; Venkata S Mattay; Michael F Egan; Daniel R Weinberger
Journal:  Arch Gen Psychiatry       Date:  2005-02

8.  Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits.

Authors:  A Strobel; L Gutknecht; C Rothe; A Reif; R Mössner; Y Zeng; B Brocke; K-P Lesch
Journal:  J Neural Transm (Vienna)       Date:  2003-01-01       Impact factor: 3.575

9.  The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers.

Authors:  F C Murphy; K A Smith; P J Cowen; T W Robbins; B J Sahakian
Journal:  Psychopharmacology (Berl)       Date:  2002-07-13       Impact factor: 4.530

10.  Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces.

Authors:  Roshan Cools; Andy J Calder; Andrew D Lawrence; Luke Clark; Ed Bullmore; Trevor W Robbins
Journal:  Psychopharmacology (Berl)       Date:  2005-09-14       Impact factor: 4.530
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  53 in total

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Authors:  Stefano Porcelli; Antonio Drago; Chiara Fabbri; Sara Gibiino; Raffaella Calati; Alessandro Serretti
Journal:  J Psychiatry Neurosci       Date:  2011-03       Impact factor: 6.186

2.  Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome.

Authors:  S Jun; R Kohen; K C Cain; M E Jarrett; M M Heitkemper
Journal:  Neurogastroenterol Motil       Date:  2010-11-12       Impact factor: 3.598

3.  A novel subpopulation of 5-HT type 3A receptor subunit immunoreactive interneurons in the rat basolateral amygdala.

Authors:  F Mascagni; A J McDonald
Journal:  Neuroscience       Date:  2006-12-05       Impact factor: 3.590

4.  Neuronal localization of 5-HT type 2A receptor immunoreactivity in the rat basolateral amygdala.

Authors:  A J McDonald; F Mascagni
Journal:  Neuroscience       Date:  2007-02-28       Impact factor: 3.590

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Journal:  Neuroimaging Clin N Am       Date:  2007-11       Impact factor: 2.264

Review 6.  [Neurogenetics of emotional processes. Neuroimaging findings as endophenotypes for depression].

Authors:  U Dannlowski; C Konrad; V Arolt; T Suslow
Journal:  Nervenarzt       Date:  2010-01       Impact factor: 1.214

Review 7.  Neuroimaging, genetics and the treatment of nicotine addiction.

Authors:  Riju Ray; James Loughead; Ze Wang; John Detre; Edward Yang; Ruben Gur; Caryn Lerman
Journal:  Behav Brain Res       Date:  2008-06-05       Impact factor: 3.332

Review 8.  Stress, genes and the biology of suicidal behavior.

Authors:  Dianne Currier; J John Mann
Journal:  Psychiatr Clin North Am       Date:  2008-06

9.  Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice.

Authors:  Lise Gutknecht; Jonas Waider; Stefanie Kraft; Claudia Kriegebaum; Bettina Holtmann; Andreas Reif; Angelika Schmitt; Klaus-Peter Lesch
Journal:  J Neural Transm (Vienna)       Date:  2008-07-30       Impact factor: 3.575

10.  The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysis.

Authors:  Guo-Lin Chen; Melinda A Novak; Jerrold S Meyer; Brian J Kelly; Eric J Vallender; Gregory M Miller
Journal:  Horm Behav       Date:  2009-11-06       Impact factor: 3.587
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