Literature DB >> 16244736

The direct alpha-zincation of amides, phosphonates and phosphine oxides by H-Zn exchange.

Mark L Hlavinka1, Jeffrey F Greco, John R Hagadorn.   

Abstract

Stoichiometric or catalytic quantities of simple 2 degrees amines greatly increase the rate of H-Zn exchange between ZnPh2 and a range of relatively non-acidic substrates, allowing for the convenient and direct preparation of alpha-functionalized organozincs.

Entities:  

Year:  2005        PMID： 16244736     DOI： 10.1039/b509190j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Alkenylation of C(sp3 )-H Bonds by Zincation/Copper-Catalyzed Cross-Coupling with Iodonium Salts.

Authors:  Chuan Liu; Qiu Wang
Journal:  Angew Chem Int Ed Engl       Date:  2018-03-15       Impact factor: 15.336

2.  Diazo compounds for the bioreversible esterification of proteins.

Authors:  Nicholas A McGrath; Kristen A Andersen; Amy K F Davis; Jo E Lomax; Ronald T Raines
Journal:  Chem Sci       Date:  2015-01-01       Impact factor: 9.825

3.  Closer insight into the reactivity of TMP-dialkyl zincates in directed ortho-zincation of anisole: experimental evidence of amido basicity and structural elucidation of key reaction intermediates.

Authors:  William Clegg; Ben Conway; Eva Hevia; Matthew D McCall; Luca Russo; Robert E Mulvey
Journal:  J Am Chem Soc       Date:  2009-02-18       Impact factor: 15.419

4.  Structurally defined potassium-mediated zincation of pyridine and 4-R-substituted pyridines (R = Et, iPr, tBu, Ph, and Me2N) by using dialkyl-TMP-zincate bases.

Authors:  William Clegg; Ben Conway; David V Graham; Eva Hevia; Alan R Kennedy; Robert E Mulvey; Luca Russo; Dominic S Wright
Journal:  Chemistry       Date:  2009-07-20       Impact factor: 5.236
  4 in total

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