Literature DB >> 16244463

Uncoupling of longevity and paraquat resistance in mutants of the nematode Caenorhabditis elegans.

Michihiko Fujii1, Nanae Tanaka, Kensuke Miki, Mohammad Nazir Hossain, Morio Endoh, Dai Ayusawa.   

Abstract

To analyze the relationship between resistance to oxidative stress and longevity, we isolated three novel paraquat-resistant mutants, mev-5, mev-6, and mev-7, from the nematode Caenorhabditis elegans. They all showed the Dyf (defective in dye filling) phenotype, but not always resistance to heat or UV. Life-span extension was observed only in the mev-5 mutant at 26 degrees C. These results indicate that longevity is uncoupled with the phenotype of paraquat resistance.

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Year:  2005        PMID： 16244463     DOI： 10.1271/bbb.69.2015

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  12 in total

Review 1.  Gene-environment interactions: neurodegeneration in non-mammals and mammals.

Authors:  Michael Aschner; Edward D Levin; Cristina Suñol; James O Olopade; Kirsten J Helmcke; Daiana S Avila; Damiyon Sledge; Rahim H Ali; Lucia Upchurch; Susan Donerly; Elwood Linney; Anna Forsby; Padmavathi Ponnuru; James R Connor
Journal:  Neurotoxicology       Date:  2010-03-30       Impact factor: 4.294

2.  Life-prolonging measures for a dead theory?

Authors:  Ulrich R Ernst; Wouter De Haes; Dries Cardoen; Liliane Schoofs
Journal:  Age (Dordr)       Date:  2013-08-17

Review 3.  The Caenorhabiditis elegans model as a reliable tool in neurotoxicology.

Authors:  Daiana Avila; Kirsten Helmcke; Michael Aschner
Journal:  Hum Exp Toxicol       Date:  2010-12-09       Impact factor: 2.903

4.  Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response.

Authors:  Keith P Choe; Kevin Strange
Journal:  Am J Physiol Cell Physiol       Date:  2008-10-01       Impact factor: 4.249

5.  A rapid colorimetric assay for the quantitation of the viability of free-living larvae of nematodes in vitro.

Authors:  Catherine E James; Mary W Davey
Journal:  Parasitol Res       Date:  2007-05-11       Impact factor: 2.289

6.  Genetic aspects of behavioral neurotoxicology.

Authors:  Edward D Levin; Michael Aschner; Ulrike Heberlein; Douglas Ruden; Kathleen A Welsh-Bohmer; Selena Bartlett; Karen Berger; Lang Chen; Ammon B Corl; Donnie Eddins; Rachael French; Kathleen M Hayden; Kirsten Helmcke; Helmut V B Hirsch; Elwood Linney; Greg Lnenicka; Grier P Page; Debra Possidente; Bernard Possidente; Annette Kirshner
Journal:  Neurotoxicology       Date:  2009-07-30       Impact factor: 4.294

7.  Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans.

Authors:  Shilpi Khare; Tara Gomez; Carole L Linster; Steven G Clarke
Journal:  Mech Ageing Dev       Date:  2009-08-12       Impact factor: 5.432

8.  Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans.

Authors:  Yaguang Ren; Su Yang; Guoqiang Tan; Wei Ye; Danhui Liu; Xu Qian; Zhongying Ding; Yuhong Zhong; Jingrui Zhang; Dandan Jiang; Yuhong Zhao; Jianxin Lu
Journal:  PLoS One       Date:  2012-01-11       Impact factor: 3.240

9.  daf-31 encodes the catalytic subunit of N alpha-acetyltransferase that regulates Caenorhabditis elegans development, metabolism and adult lifespan.

Authors:  Di Chen; Jiuli Zhang; Justin Minnerly; Tiffany Kaul; Donald L Riddle; Kailiang Jia
Journal:  PLoS Genet       Date:  2014-10-16       Impact factor: 5.917

Review 10.  Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology.

Authors:  Maxwell C K Leung; Phillip L Williams; Alexandre Benedetto; Catherine Au; Kirsten J Helmcke; Michael Aschner; Joel N Meyer
Journal:  Toxicol Sci       Date:  2008-06-19       Impact factor: 4.849
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