Literature DB >> 1624366

The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.

M J Dawson1, J E Farthing, P S Marshall, R F Middleton, M J O'Neill, A Shuttleworth, C Stylli, R M Tait, P M Taylor, H G Wildman.   

Abstract

During the screening of fungi for inhibitors of squalene synthase, Phoma sp. C2932 was found to produce three structurally related novel inhibitors. These compounds, designated the squalestatins, exhibited potent activity against both mammalian (rat liver) and fungal (Candida albicans) squalene synthase. Furthermore, they also had broad spectrum in vitro antifungal activity.

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Year:  1992        PMID： 1624366     DOI： 10.7164/antibiotics.45.639

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  13 in total

Review 1.  Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Authors:  K C Nicolaou; Christopher R H Hale; Christian Nilewski; Heraklidia A Ioannidou
Journal:  Chem Soc Rev       Date:  2012-06-28       Impact factor: 54.564

Review 2.  Antifungal agents: chemotherapeutic targets and immunologic strategies.

Authors:  N H Georgopapadakou; T J Walsh
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

Review 3.  Recent examples of novel secondary metabolites.

Authors:  A G Brown
Journal:  Folia Microbiol (Praha)       Date:  1995       Impact factor: 2.099

4.  Navigating the fungal polyketide chemical space: from genes to molecules.

Authors:  Yit-Heng Chooi; Yi Tang
Journal:  J Org Chem       Date:  2012-09-13       Impact factor: 4.354

5.  Silyl glyoxylates. Conception and realization of flexible conjunctive reagents for multicomponent coupling.

Authors:  Gregory R Boyce; Stephen N Greszler; Jeffrey S Johnson; Xin Linghu; Justin T Malinowski; David A Nicewicz; Andrew D Satterfield; Daniel C Schmitt; Kimberly M Steward
Journal:  J Org Chem       Date:  2012-03-23       Impact factor: 4.354

6.  Squalestatin is an inhibitor of carotenoid biosynthesis in Plasmodium falciparum.

Authors:  Heloisa B Gabriel; Marcia F Silva; Emília A Kimura; Gerhard Wunderlich; Alejandro M Katzin; Mauro F Azevedo
Journal:  Antimicrob Agents Chemother       Date:  2015-03-16       Impact factor: 5.191

Review 7.  Promising antimicrobials from Phoma spp.: progress and prospects.

Authors:  Mahendra Rai; Beata Zimowska; Aniket Gade; Pramod Ingle
Journal:  AMB Express       Date:  2022-05-23       Impact factor: 4.126

8.  Self-consistent synthesis of the squalene synthase inhibitor zaragozic acid C via controlled oligomerization.

Authors:  David A Nicewicz; Andrew D Satterfield; Daniel C Schmitt; Jeffrey S Johnson
Journal:  J Am Chem Soc       Date:  2008-12-24       Impact factor: 15.419

9.  Enantiospecific total synthesis of the squalene synthase inhibitors (-)-CJ-13,982 and its enantiomer from a common intermediate.

Authors:  Dayna Sturgess; Zongjia Chen; Jonathan M White; Mark A Rizzacasa
Journal:  J Antibiot (Tokyo)       Date:  2017-10-25       Impact factor: 2.649

10.  Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.

Authors:  J D Bergstrom; M M Kurtz; D J Rew; A M Amend; J D Karkas; R G Bostedor; V S Bansal; C Dufresne; F L VanMiddlesworth; O D Hensens
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-01       Impact factor: 11.205
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