Literature DB >> 16243263

The role of nanobiotechnology in drug discovery.

Kewal K Jain1.   

Abstract

The application of nanotechnology in life sciences, nanobiotechnology, is already having an impact on diagnostics and drug delivery. Now, researchers are starting to use nanotechnology in the field of drug discovery. This review explains how several technologies, including nanoparticles and nanodevices such as nanobiosensors and nanobiochips, are used to improve drug discovery and development. Nanoscale assays can contribute significantly to cost-saving in screening campaigns. In addition, some nanosubstances (such as fullerenes) could be potential drugs for the future. Although there might be some safety concerns with respect to the in vivo use of nanoparticles, studies are in place to determine the nature and extent of adverse events. Future prospects for the application of nanotechnology in healthcare and for the development of personalized medicine appear to be excellent.

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Year:  2005        PMID: 16243263     DOI: 10.1016/S1359-6446(05)03573-7

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  21 in total

1.  Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery.

Authors:  Huanyu Dou; Christopher J Destache; Justin R Morehead; R Lee Mosley; Michael D Boska; Jeffrey Kingsley; Santhi Gorantla; Larisa Poluektova; Jay A Nelson; Mahesh Chaubal; Jane Werling; James Kipp; Barrett E Rabinow; Howard E Gendelman
Journal:  Blood       Date:  2006-06-29       Impact factor: 22.113

Review 2.  Nanoparticles: pharmacological and toxicological significance.

Authors:  C Medina; M J Santos-Martinez; A Radomski; O I Corrigan; M W Radomski
Journal:  Br J Pharmacol       Date:  2007-01-22       Impact factor: 8.739

Review 3.  Nanoscale monitoring of drug actions on cell membrane using atomic force microscopy.

Authors:  Mi Li; Lian-qing Liu; Ning Xi; Yue-chao Wang
Journal:  Acta Pharmacol Sin       Date:  2015-06-01       Impact factor: 6.150

Review 4.  Uniqueness, advantages, challenges, solutions, and perspectives in therapeutics applying RNA nanotechnology.

Authors:  Peixuan Guo; Farzin Haque; Brent Hallahan; Randall Reif; Hui Li
Journal:  Nucleic Acid Ther       Date:  2012-08       Impact factor: 5.486

Review 5.  Assembly of multifunctional phi29 pRNA nanoparticles for specific delivery of siRNA and other therapeutics to targeted cells.

Authors:  Yi Shu; Mathieu Cinier; Dan Shu; Peixuan Guo
Journal:  Methods       Date:  2011-02-12       Impact factor: 3.608

Review 6.  Engineering RNA for targeted siRNA delivery and medical application.

Authors:  Peixuan Guo; Oana Coban; Nicholas M Snead; Joe Trebley; Steve Hoeprich; Songchuan Guo; Yi Shu
Journal:  Adv Drug Deliv Rev       Date:  2010-03-15       Impact factor: 15.470

7.  Targeted delivery of siRNA into breast cancer cells via phage fusion proteins.

Authors:  Deepa Bedi; James W Gillespie; Vasily A Petrenko; Andreas Ebner; Michael Leitner; Peter Hinterdorfer; Valery A Petrenko
Journal:  Mol Pharm       Date:  2013-01-08       Impact factor: 4.939

8.  Macrophage delivery of nanoformulated antiretroviral drug to the brain in a murine model of neuroAIDS.

Authors:  Huanyu Dou; Cassi B Grotepas; JoEllyn M McMillan; Christopher J Destache; Mahesh Chaubal; Jane Werling; James Kipp; Barrett Rabinow; Howard E Gendelman
Journal:  J Immunol       Date:  2009-06-17       Impact factor: 5.422

9.  Specific Delivery of MiRNA for High Efficient Inhibition of Prostate Cancer by RNA Nanotechnology.

Authors:  Daniel W Binzel; Yi Shu; Hui Li; Meiyan Sun; Qunshu Zhang; Dan Shu; Bin Guo; Peixuan Guo
Journal:  Mol Ther       Date:  2016-04-29       Impact factor: 11.454

10.  Fabrication of pRNA nanoparticles to deliver therapeutic RNAs and bioactive compounds into tumor cells.

Authors:  Yi Shu; Dan Shu; Farzin Haque; Peixuan Guo
Journal:  Nat Protoc       Date:  2013-08-01       Impact factor: 13.491

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