Literature DB >> 16242648

The stereochemistry of ketoreduction.

Patrick Caffrey1.   

Abstract

In this issue of Chemistry & Biology, Leadlay and coworkers report overproduction of a number of ketoreductase domains from modular polyketide synthases. These discrete enzymes allow the stereochemistry of polyketide ketoreduction to be studied in isolation.

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Year:  2005        PMID: 16242648     DOI: 10.1016/j.chembiol.2005.10.002

Source DB:  PubMed          Journal:  Chem Biol        ISSN: 1074-5521


  7 in total

1.  Structural basis of functional group activation by sulfotransferases in complex metabolic pathways.

Authors:  Jennifer Gehret McCarthy; Eli B Eisman; Sarang Kulkarni; Lena Gerwick; William H Gerwick; Peter Wipf; David H Sherman; Janet L Smith
Journal:  ACS Chem Biol       Date:  2012-09-26       Impact factor: 5.100

2.  Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module.

Authors:  Yousong Ding; Christopher M Rath; Kyle L Bolduc; Kristina Håkansson; David H Sherman
Journal:  J Am Chem Soc       Date:  2011-08-25       Impact factor: 15.419

3.  Structural and biochemical analyses of regio- and stereospecificities observed in a type II polyketide ketoreductase.

Authors:  Pouya Javidpour; Tyler Paz Korman; Gaurav Shakya; Shiou-Chuan Tsai
Journal:  Biochemistry       Date:  2011-05-04       Impact factor: 3.162

4.  Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis.

Authors:  Liangcai Gu; Bo Wang; Amol Kulkarni; Jennifer J Gehret; Kayla R Lloyd; Lena Gerwick; William H Gerwick; Peter Wipf; Kristina Håkansson; Janet L Smith; David H Sherman
Journal:  J Am Chem Soc       Date:  2009-11-11       Impact factor: 15.419

Review 5.  Dissecting complex polyketide biosynthesis.

Authors:  Patrick Caffrey
Journal:  Comput Struct Biotechnol J       Date:  2012-11-17       Impact factor: 7.271

6.  Structural insight into the tetramerization of an iterative ketoreductase siam through aromatic residues in the interfaces.

Authors:  Hua Wang; Huaidong Zhang; Yi Zou; Yanling Mi; Shuangjun Lin; Zhixiong Xie; Yunjun Yan; Houjin Zhang
Journal:  PLoS One       Date:  2014-06-05       Impact factor: 3.240

7.  A standardized workflow for submitting data to the Minimum Information about a Biosynthetic Gene cluster (MIBiG) repository: prospects for research-based educational experiences.

Authors:  Samuel C Epstein; Louise K Charkoudian; Marnix H Medema
Journal:  Stand Genomic Sci       Date:  2018-07-11
  7 in total

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