| Literature DB >> 16242328 |
Nan-Horng Lin1, Ping Xia, Peter Kovar, Chang Park, Zehan Chen, Haiying Zhang, Saul H Rosenberg, Hing L Sham.
Abstract
Chk1 inhibitors have emerged as a novel class of neoplastic agents for abrogating the G2 DNA damage checkpoint arrest. Analogs of the Chk1 inhibitor, 3-ethylidene-1,3-dihydro-indol-2-one, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analog 28, which possesses potent enzymatic and cellular activities.Entities:
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Year: 2005 PMID： 16242328 DOI： 10.1016/j.bmcl.2005.09.064
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823