| Literature DB >> 16242327 |
Takayoshi Kinoshita1, Masaichi Warizaya, Makoto Ohori, Kentaro Sato, Masahiro Neya, Takashi Fujii.
Abstract
A series of pyrazolopyridazine compounds were briefly investigated as ERK2 inhibitors. The crystal structure of ERK2 complexed with an allyl derivative was determined. The compound induces structural change including movement of the glycine-rich loop and peptide flip between Met108-Glu109. As a result, the newly formed subsite can recognize small hydrophobic substituents but not hydrophilic ones.Entities:
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Year: 2005 PMID： 16242327 DOI： 10.1016/j.bmcl.2005.09.055
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823