| Literature DB >> 16242326 |
Raquel Pereira1, Claudine Gaudon, Beatriz Iglesias, Pierre Germain, Hinrich Gronemeyer, Angel R de Lera.
Abstract
Sequential, position-selective, Pd-catalyzed cross-coupling reactions of 2,4-dibromo-5-hydroxymethylthiazole provided the scaffold for the synthesis of GW501516, the most potent PPARbeta/delta agonist yet described, and equally selective analogs at the thiazole-C4 position.Entities:
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Year: 2005 PMID： 16242326 DOI： 10.1016/j.bmcl.2005.09.060
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823