Literature DB >> 16241902

A construction of pooling designs with some happy surprises.

A D'Yachkov1, Frank Hwang, Antony Macula, Pavel Vilenkin, Chih-Wen Weng.   

Abstract

The screening of data sets for "positive data objects" is essential to modern technology. A (group) test that indicates whether a positive data object is in a specific subset or pool of the dataset can greatly facilitate the identification of all the positive data objects. A collection of tested pools is called a pooling design. Pooling designs are standard experimental tools in many biotechnical applications. In this paper, we use the (linear) subspace relation coupled with the general concept of a "containment matrix" to construct pooling designs with surprisingly high degrees of error correction (detection.) Error-correcting pooling designs are important to biotechnical applications where error rates often are as high as 15%. What is also surprising is that the rank of the pooling design containment matrix is independent of the number of positive data objects in the dataset.

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Year:  2005        PMID: 16241902     DOI: 10.1089/cmb.2005.12.1129

Source DB:  PubMed          Journal:  J Comput Biol        ISSN: 1066-5277            Impact factor:   1.479


  1 in total

1.  Pooled screening for synergistic interactions subject to blocking and noise.

Authors:  Kyle Li; Doina Precup; Theodore J Perkins
Journal:  PLoS One       Date:  2014-01-16       Impact factor: 3.240

  1 in total

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