Literature DB >> 16239906

Promoting apoptosis as a strategy for cancer drug discovery.

Stephen W Fesik1.   

Abstract

Apoptosis is deregulated in many cancers, making it difficult to kill tumours. Drugs that restore the normal apoptotic pathways have the potential for effectively treating cancers that depend on aberrations of the apoptotic pathway to stay alive. Apoptosis targets that are currently being explored for cancer drug discovery include the tumour-necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors, the BCL2 family of anti-apoptotic proteins, inhibitor of apoptosis (IAP) proteins and MDM2.

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Year:  2005        PMID： 16239906     DOI： 10.1038/nrc1736

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  324 in total

1.  High-fat feeding does not induce an autophagic or apoptotic phenotype in female rat skeletal muscle.

Authors:  Troy L Campbell; Andrew S Mitchell; Elliott M McMillan; Darin Bloemberg; Dmytro Pavlov; Isabelle Messa; John G Mielke; Joe Quadrilatero
Journal:  Exp Biol Med (Maywood)       Date:  2014-10-30

2.  Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity.

Authors:  Yi-Fong Chen; Yi-Chien Lin; Susan L Morris-Natschke; Chen-Fang Wei; Ting-Chen Shen; Hui-Yi Lin; Mei-Hua Hsu; Li-Chen Chou; Yu Zhao; Sheng-Chu Kuo; Kuo-Hsiung Lee; Li-Jiau Huang
Journal:  Br J Pharmacol       Date:  2015-01-13       Impact factor: 8.739

3.  Modulation of RNA splicing as a potential treatment for cancer.

Authors:  John A Bauman; Ryszard Kole
Journal:  Bioeng Bugs       Date:  2011-05-01

4.  Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison.

Authors:  Wasamon Nutakul; Hana Shatara Sobers; Peiju Qiu; Ping Dong; Eric Andrew Decker; David Julian McClements; Hang Xiao
Journal:  J Agric Food Chem       Date:  2011-09-29       Impact factor: 5.279

5.  In cancer drug resistance, germline matters too.

Authors:  Emily H Cheng; Charles L Sawyers
Journal:  Nat Med       Date:  2012-04-05       Impact factor: 53.440

6.  ApoptoProteomics, an integrated database for analysis of proteomics data obtained from apoptotic cells.

Authors:  Magnus Ø Arntzen; Bernd Thiede
Journal:  Mol Cell Proteomics       Date:  2011-11-08       Impact factor: 5.911

7.  Inducing Apoptosis and Decreasing Cell Proliferation in Human Acute Promyelocytic Leukemia Through Regulation Expression of CASP3 by Let-7a-5p Blockage.

Authors:  Mahdi Fasihi-Ramandi; Abbas Moridnia; Ali Najafi; Mohammadreza Sharifi
Journal:  Indian J Hematol Blood Transfus       Date:  2017-03-29       Impact factor: 0.900

8.  Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes.

Authors:  Satya Sree N Kolar; Rola Barhoumi; Evelyn S Callaway; Yang-Yi Fan; Naisyin Wang; Joanne R Lupton; Robert S Chapkin
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2007-08-23       Impact factor: 4.052

9.  Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis.

Authors:  Sean L Petersen; Lai Wang; Asligul Yalcin-Chin; Lin Li; Michael Peyton; John Minna; Patrick Harran; Xiaodong Wang
Journal:  Cancer Cell       Date:  2007-11       Impact factor: 31.743

10.  Evidence that membrane insertion of the cytosolic domain of Bcl-xL is governed by an electrostatic mechanism.

Authors:  Guruvasuthevan R Thuduppathy; Jeffrey W Craig; Victoria Kholodenko; Arne Schon; R Blake Hill
Journal:  J Mol Biol       Date:  2006-04-06       Impact factor: 5.469
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