AIM: To study the effect of SNC19/ST14 gene overexpression on invasion in vitro of colorectal cancer cells. METHODS: The adhesion of SNC19/ST14 gene-transfected cells to ECM was measured by MTT assay. The cell movement was evaluated by wound healing assay. Cell invasion and migration were determined by invasion assay in vitro. RESULTS: SNC19/ST14 gene overexpression could enhance invasion of colorectal cancer cells in vitro significantly and influence early cell adherence to ECM, but could not change cell movement significantly. CONCLUSION: SNC19/ST14 gene overexpression increases the local invasion of colorectal cancer cells in vitro.
AIM: To study the effect of SNC19/ST14 gene overexpression on invasion in vitro of colorectal cancer cells. METHODS: The adhesion of SNC19/ST14 gene-transfected cells to ECM was measured by MTT assay. The cell movement was evaluated by wound healing assay. Cell invasion and migration were determined by invasion assay in vitro. RESULTS:SNC19/ST14 gene overexpression could enhance invasion of colorectal cancer cells in vitro significantly and influence early cell adherence to ECM, but could not change cell movement significantly. CONCLUSION:SNC19/ST14 gene overexpression increases the local invasion of colorectal cancer cells in vitro.
Authors: L Naldini; L Tamagnone; E Vigna; M Sachs; G Hartmann; W Birchmeier; Y Daikuhara; H Tsubouchi; F Blasi; P M Comoglio Journal: EMBO J Date: 1992-12 Impact factor: 11.598