| Literature DB >> 16236498 |
Mark R Spyvee1, Huiming Zhang, Lynn D Hawkins, Jesse C Chow.
Abstract
Novel synthetic phospholipid compound 1 was discovered to be an antagonist of human toll-like receptor 2 (TLR2) signaling. In a preliminary SAR campaign we synthesized several analogues of 1 and found that considerable structural changes could be made without loss of TLR2 antagonistic activity.Entities:
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Year: 2005 PMID： 16236498 DOI： 10.1016/j.bmcl.2005.08.080
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823