| Literature DB >> 16235928 |
Masayuki Matsushita1, Michael M Meijler, Peter Wirsching, Richard A Lerner, Kim D Janda.
Abstract
[reaction: see text] A chemically programmed antibody sensor, consisting of a stilbenyl boronic acid cofactor and monoclonal antibody EP2-19G2, provides a new method of mercury detection. The fluorescent antibody sensor generates an intense powder blue fluorescence when bound to the stilbenyl boronic acid cofactor; however, it is quenched in the presence of Hg(2+) ions. The EP2-19G2-cofactor biosensor provides micromolar sensitivity and selectivity toward Hg(2+) ions over a wide range of metal ions in aqueous solution.Entities:
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Year: 2005 PMID： 16235928 DOI： 10.1021/ol051919w
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005