BACKGROUND: Tuberculosis is one of the most common infectious diseases in the world. In recent years, genetically approach has been developed. One of the interesting gene for investigator is IFN-gammaR1. AIM: Determination of susceptibility to tuberculosis with polymorphism of IFN-gammaR1 gene. MATERIAL AND METHOD: Study was prospective case-control. Fifty patients with smear positive tuberculosis have been chosen randomly. They were matched with 54 healthy controls with no history of TB. Polymorphism at 395 codon of IFN-gammaR1 gene was detected with Newport method. Data were analysed with SPSS version 11. RESULTS: Mean age of patients and control were 55+/-20 and 53+/-13.5 years, respectively. Demographic characteristic had no difference within two groups. One patient in case group had heterozygote mutation at IFN-gammaR1 gene. In control group there were no mutations. CONCLUSION: Genetically susceptibility to TB is not in 395 colon of IFN-gammaR1 in Iranian TB sample and polymorphism of this loci has occur in 2% of TB patients and 0.96% of total study population.
BACKGROUND:Tuberculosis is one of the most common infectious diseases in the world. In recent years, genetically approach has been developed. One of the interesting gene for investigator is IFN-gammaR1. AIM: Determination of susceptibility to tuberculosis with polymorphism of IFN-gammaR1 gene. MATERIAL AND METHOD: Study was prospective case-control. Fifty patients with smear positive tuberculosis have been chosen randomly. They were matched with 54 healthy controls with no history of TB. Polymorphism at 395 codon of IFN-gammaR1 gene was detected with Newport method. Data were analysed with SPSS version 11. RESULTS: Mean age of patients and control were 55+/-20 and 53+/-13.5 years, respectively. Demographic characteristic had no difference within two groups. One patient in case group had heterozygote mutation at IFN-gammaR1 gene. In control group there were no mutations. CONCLUSION: Genetically susceptibility to TB is not in 395 colon of IFN-gammaR1 in Iranian TB sample and polymorphism of this loci has occur in 2% of TBpatients and 0.96% of total study population.
Authors: Ana Cristina C S Leandro; Márcia Andrade Rocha; Andreia Lamoglia-Souza; John L VandeBerg; Valeria Cavalcanti Rolla; Maria da Gloria Bonecini-Almeida Journal: Biomed Res Int Date: 2013-08-18 Impact factor: 3.411
Authors: Mohammad Varahram; Parissa Farnia; Mohammad Javad Nasiri; Mona Afraei Karahrudi; Mehdi Kazempour Dizagie; Ali Akbar Velayati Journal: Mediterr J Hematol Infect Dis Date: 2014-02-16 Impact factor: 2.576