Knowledge-based design and operation of bioprocess systems.

Almost twenty years have passed since the first applications of the knowledge-based approach to bioprocess operations were reported. During this period, approaches such as fuzzy logic, artificial neural network modeling, expert systems and genetic algorithms have been extensively studied and successfully used in the design and control of various bioprocesses. The recent development of these approaches in the design and operation of biological processes is summarized and reviewed, especially focusing on the studies reported in biochemical engineering journals.