Literature DB >> 1623167

A role for interleukin-2 in the regulation of striatal dopaminergic function.

P A Lapchak1.   

Abstract

The present study determined whether interleukin-2 (IL-2) is endogenous to the normal adult rat striatum and whether IL-2 regulates striatal dopaminergic tone. IL-2 mRNA (1.5 kb size), endogenous IL-2 and IL-2 receptors were found to be distributed throughout the rat striatum in moderate densities. Application of exogenous IL-2 to striatal slices in in vitro produced significant increases in both spontaneous and potassium (25 mM)-evoked [3H] dopamine release. The modulatory effect of IL-2 was dependent on the presence of external calcium and required axonal nerve activity, since IL-2 was unable to increase transmitter release under low external calcium conditions or in the presence of tetrodotoxin. Overall, this study indicates that IL-2 may be an endogenous neurokine that regulates striatal dopaminergic function in normal animals.

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Year:  1992        PMID： 1623167     DOI： 10.1097/00001756-199202000-00011

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


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