| Literature DB >> 16231421 |
John R Yates1, Annalyn Gilchrist, Kathryn E Howell, John J M Bergeron.
Abstract
The mass-spectrometry-based identification of proteins has created opportunities for the study of organelles, transport intermediates and large subcellular structures. Traditional cell-biology techniques are used to enrich these structures for proteomics analyses, and such analyses provide insights into the biology and functions of these structures. Here, we review the state-of-the-art proteomics techniques for the analysis of subcellular structures and discuss the biological insights that have been derived from such studies.Mesh：
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Year: 2005 PMID： 16231421 DOI： 10.1038/nrm1711
Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444