Literature DB >> 16230789

Effect of the Pro12Ala polymorphism of the PPARg2 gene on serum adiponectin changes.

Firoozeh Mousavinasab1, Tuula Tähtinen, Jari Jokelainen, Pentti Koskela, Mauno Vanhala, Jorma Oikarinen, Sirkka Keinänen-Kiukaanniemi, Markku Laakso.   

Abstract

The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) gene and adiponectin, a protein secreted from adipose tissue, have been associated with insulin sensitivity. The present study demonstrates that in Finnish servicemen who were on a high-caloric diet for 6 mo only subjects with the Ala 12 allele of PPARgamma2 had a significant increase in adiponectin levels with weight loss induced by heavy exercise. This study demonstrates an interaction of genetic and environmental factors in the regulation of serum adiponectin concentrations.

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Year:  2005        PMID： 16230789     DOI： 10.1385/endo:27:3:307

Source DB:  PubMed          Journal:  Endocrine        ISSN： 1355-008X            Impact factor:   3.925


  8 in total

1.  No influence of the PPARgamma2 Pro12Ala genotype on serum adiponectin concentrations in healthy Europeans.

Authors:  Claus Thamer; Fausto Machicao; Andreas Fritsche; Michael Stumvoll; Hans Häring
Journal:  Metabolism       Date:  2003-06       Impact factor: 8.694

Review 2.  PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

Authors:  B M Spiegelman
Journal:  Diabetes       Date:  1998-04       Impact factor: 9.461

3.  PPAR(gamma)2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population.

Authors:  Yukihiro Yamamoto; Hiroshi Hirose; Kiichi Miyashita; Kanako Nishikai; Ikuo Saito; Matsuo Taniyama; Motowo Tomita; Takao Saruta
Journal:  Metabolism       Date:  2002-11       Impact factor: 8.694

4.  Lack of increase of serum adiponectin concentrations with a moderate weight loss during six months on a high-caloric diet in military service among a young male Finnish population.

Authors:  Firoozeh Mousavinasab; Tuula Tähtinen; Jari Jokelainen; Pentti Koskela; Mauno Vanhala; Jorma Oikarinen; Sirkka Keinänen-Kiukaanniemi
Journal:  Endocrine       Date:  2005-02       Impact factor: 3.633

5.  Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men.

Authors:  Firoozeh Mousavinasab; Tuula Tähtinen; Jari Jokelainen; Pentti Koskela; Mauno Vanhala; Jorma Oikarinen; Sirkka Keinänen-Kiukaanniemi; Markku Laakso
Journal:  Mol Genet Metab       Date:  2005-01-25       Impact factor: 4.797

Review 6.  The mechanisms of action of PPARs.

Authors:  Joel Berger; David E Moller
Journal:  Annu Rev Med       Date:  2002       Impact factor: 13.739

7.  Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population.

Authors:  Yukihiro Yamamoto; Hiroshi Hirose; Ikuo Saito; Motowo Tomita; Matsuo Taniyama; Koichi Matsubara; Yasunori Okazaki; Tatsuya Ishii; Kanako Nishikai; Takao Saruta
Journal:  Clin Sci (Lond)       Date:  2002-08       Impact factor: 6.124

8.  A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity.

Authors:  S S Deeb; L Fajas; M Nemoto; J Pihlajamäki; L Mykkänen; J Kuusisto; M Laakso; W Fujimoto; J Auwerx
Journal:  Nat Genet       Date:  1998-11       Impact factor: 38.330
  8 in total
  8 in total

Review 1.  Effect of genotype on success of lifestyle intervention in subjects at risk for type 2 diabetes.

Authors:  Peter Weyrich; Norbert Stefan; Hans-Ulrich Häring; Markku Laakso; Andreas Fritsche
Journal:  J Mol Med (Berl)       Date:  2006-12-13       Impact factor: 4.599

2.  The Pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone-binding globulin level and its relationship to the development of the metabolic syndrome in young Finnish men.

Authors:  Firoozeh Mousavinasab; Tuula Tähtinen; Jari Jokelainen; Pentti Koskela; Mauno Vanhala; Jorma Oikarinen; Markku Laakso; Sirkka Keinänen-Kiukaanniemi
Journal:  Endocrine       Date:  2006-10       Impact factor: 3.633

3.  PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor.

Authors:  Dharambir Kaur Sanghera; Fatma Yesim Demirci; Latonya Been; Lyda Ortega; Sarju Ralhan; Gurpreet Singh Wander; Narinder Kumar Mehra; Jairup Singh; Christopher Eric Aston; John Joseph Mulvihill; Ilyas Mohammad Kamboh
Journal:  Metabolism       Date:  2009-10-20       Impact factor: 8.694

4.  Correlation between adiponectin polymorphisms and non-alcoholic fatty liver disease with or without metabolic syndrome in Chinese population.

Authors:  Z L Wang; B Xia; U Shrestha; L Jiang; C W Ma; Q Chen; H Chen; Z G Hu
Journal:  J Endocrinol Invest       Date:  2008-12       Impact factor: 4.256

5.  Application of network construction to estimate functional changes to insulin receptor substrates 1 and 2 in Huh7 cells following infection with the hepatitis C virus.

Authors:  Jingkun Liu; Linbang Wang; Wenjun Wang; Yaping Li; Xiaoli Jia; Song Zhai; Juan Shi; Shuangsuo Dang
Journal:  Mol Med Rep       Date:  2016-07-18       Impact factor: 2.952

6.  Genetic polymorphisms of the main transcription factors for adiponectin gene promoter in regulation of adiponectin levels: association analysis in three European cohorts.

Authors:  Lyudmyla Kedenko; Claudia Lamina; Tobias Kiesslich; Karen Kapur; Sven Bergmann; Dawn Waterworth; Iris M Heid; H-Erich Wichmann; Igor Kedenko; Florian Kronenberg; Bernhard Paulweber
Journal:  PLoS One       Date:  2012-12-21       Impact factor: 3.240

7.  PPARγ2 polymorphism and human health.

Authors:  Weimin He
Journal:  PPAR Res       Date:  2009-04-16       Impact factor: 4.964

8.  The Genetics of PPARG and the Skeleton.

Authors:  Cheryl Ackert-Bicknell; Clifford Rosen
Journal:  PPAR Res       Date:  2006       Impact factor: 4.964
  8 in total

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