HYPOTHESIS: Transdermal sustained-delivery oxygen therapy improves wound healing. DESIGN: Experimental study using a well-established rabbit ear model for acute wound healing. SETTING: Wound-healing research laboratory in a university center. METHODS: Four full-thickness 7-mm punch wounds were created on each ear of young, female New Zealand white rabbits. Treated ears received transdermal sustained delivery of oxygen via silicone tubing tunneled subcutaneously to a pocket under a semiocclusive dressing. Oxygen production (100% oxygen at 3 mL/h continuously) relied on a small, self-contained device connected to the silicone tubing and secured to the rabbit's back for the duration of the experiment using a body harness. Ears were harvested at each of 2 time points: day 5 and day 8. RESULTS: Histologic analysis of the wounds showed significantly greater healing at both day 5 and day 8 in response to oxygen therapy. Most significantly, epithelial wound coverage was almost doubled in treated ear wounds when compared with controls. CONCLUSION: Our results suggest that epithelial wound healing is improved by transdermal sustained-delivery treatment with 100% oxygen.
HYPOTHESIS: Transdermal sustained-delivery oxygen therapy improves wound healing. DESIGN: Experimental study using a well-established rabbit ear model for acute wound healing. SETTING: Wound-healing research laboratory in a university center. METHODS: Four full-thickness 7-mm punch wounds were created on each ear of young, female New Zealand white rabbits. Treated ears received transdermal sustained delivery of oxygen via silicone tubing tunneled subcutaneously to a pocket under a semiocclusive dressing. Oxygen production (100% oxygen at 3 mL/h continuously) relied on a small, self-contained device connected to the silicone tubing and secured to the rabbit's back for the duration of the experiment using a body harness. Ears were harvested at each of 2 time points: day 5 and day 8. RESULTS: Histologic analysis of the wounds showed significantly greater healing at both day 5 and day 8 in response to oxygen therapy. Most significantly, epithelial wound coverage was almost doubled in treated ear wounds when compared with controls. CONCLUSION: Our results suggest that epithelial wound healing is improved by transdermal sustained-delivery treatment with 100% oxygen.
Authors: Joe F Lo; Martin Brennan; Zameer Merchant; Lin Chen; Shujuan Guo; David T Eddington; Luisa A DiPietro Journal: Wound Repair Regen Date: 2013-02-25 Impact factor: 3.617
Authors: Thomas K Hunt; Rummana S Aslam; Stefan Beckert; Silvia Wagner; Q Perveen Ghani; M Zamirul Hussain; Sashwati Roy; Chandan K Sen Journal: Antioxid Redox Signal Date: 2007-08 Impact factor: 8.401
Authors: Giorgio Pietramaggiori; Saja S Scherer; Jasmine C Mathews; Tony Gennaoui; Luca Lancerotto; Gina Ragno; C Robert Valeri; Dennis P Orgill Journal: J Surg Res Date: 2008-10-10 Impact factor: 2.192