Literature DB >> 16229967

Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages.

Eun-Mi Choi1, Jae-Kwan Hwang.   

Abstract

Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 microg/ml. LPS-induced PGE2 production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significantly decreased the production of TNF-alpha. These findings suggest that M. alba leaf extract seems to be able in suppressing inflammatory mediators. Moreover, the inhibitory activities on COX-2 and iNOS of its butanol fraction are warranted for further elucidation of active principles for development of new antiinflammatory agents.

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Year:  2005        PMID： 16229967     DOI： 10.1016/j.fitote.2005.05.006

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  21 in total

1.  Stevioside suppressed inflammatory cytokine secretion by downregulation of NF-κB and MAPK signaling pathways in LPS-stimulated RAW264.7 cells.

Authors:  Li Fengyang; Fu Yunhe; Liu Bo; Liu Zhicheng; Li Depeng; Liang Dejie; Zhang Wen; Cao Yongguo; Zhang Naisheng; Zhang Xichen; Yang Zhengtao
Journal:  Inflammation       Date:  2012-10       Impact factor: 4.092

2.  Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism.

Authors:  Ayman M Mahmoud; Sanaa M Abd El-Twab; Eman S Abdel-Reheim
Journal:  Eur J Nutr       Date:  2016-04-08       Impact factor: 5.614

3.  Antioxidant and anti-inflammatory effects of an ethanol fraction from the Schisandra chinensis baillon hot water extract fermented using Lactobacilius paracasei subsp. tolerans.

Authors:  Jung Yoon Yang; Geum Ran Kim; Jin Sil Chae; Hyemin Kan; Seong Soon Kim; Kyu-Seok Hwang; Byung Hoi Lee; Sangcheol Yu; Seongcheol Moon; Byounghee Park; Myung Ae Bae; Dae-Seop Shin
Journal:  Food Sci Biotechnol       Date:  2019-06-07       Impact factor: 2.391

4.  Combined treatment of mulberry leaf and fruit extract ameliorates obesity-related inflammation and oxidative stress in high fat diet-induced obese mice.

Authors:  Hyun Hwa Lim; Soo Jin Yang; Yuri Kim; Myoungsook Lee; Yunsook Lim
Journal:  J Med Food       Date:  2013-08       Impact factor: 2.786

5.  A leaf methanolic extract of Wercklea insignis attenuates the lipopolysaccharide-induced inflammatory response by blocking the NF-κB signaling pathway in RAW 264.7 macrophages.

Authors:  Ji-Won Park; Ok-Kyoung Kwon; Ha-young Jang; Hyeok Jeong; Sei-Ryang Oh; Hyeong-Kyu Lee; Sang-Bae Han; Kyung-Seop Ahn
Journal:  Inflammation       Date:  2012-02       Impact factor: 4.092

6.  Magnolol inhibits LPS-induced inflammatory response in uterine epithelial cells : magnolol inhibits LPS-induced inflammatory response.

Authors:  Jia Luo; Yanwen Xu; Minfang Zhang; Ling Gao; Cong Fang; Canquan Zhou
Journal:  Inflammation       Date:  2013-10       Impact factor: 4.092

7.  Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling.

Authors:  Yi-Ching Chen; Yin-Jing Tien; Chun-Houh Chen; Francesca N Beltran; Evangeline C Amor; Ran-Juh Wang; Den-Jen Wu; Clément Mettling; Yea-Lih Lin; Wen-Chin Yang
Journal:  BMC Complement Altern Med       Date:  2013-02-23       Impact factor: 3.659

8.  Protective effects of the Morus alba L. leaf extracts on cisplatin-induced nephrotoxicity in rat.

Authors:  M Nematbakhsh; V Hajhashemi; A Ghannadi; A Talebi; M Nikahd
Journal:  Res Pharm Sci       Date:  2013-04

9.  Effects of alpha-mangostin on the expression of anti-inflammatory genes in U937 cells.

Authors:  Szu-Hsiu Liu; Lain-Tze Lee; Nai-Yun Hu; Kuo-Kuei Huange; Ying-Chu Shih; Iinuma Munekazu; Jen-Ming Li; Ting-Yu Chou; Wei-Hsin Wang; Ting-Shou Chen
Journal:  Chin Med       Date:  2012-08-24       Impact factor: 5.455

10.  Effects of plant-based Korean food extracts on lipopolysaccharide-stimulated production of inflammatory mediators in vitro.

Authors:  Sun Young Lee; Yoo-Sun Kim; Ji Ye Lim; Namsoo Chang; Myung-Hee Kang; Se-Young Oh; He-Jin Lee; Hyesook Kim; Yuri Kim
Journal:  Nutr Res Pract       Date:  2014-05-15       Impact factor: 1.926
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