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Literature DB >> 16228221

Antagonistic combinations of occupational carcinogens.

Abstract

Several epidemiological and experimental studies demonstrate that combinations of carcinogens may interact in a synergistic way. This has prompted speculations that modulating interactions of individual chemical carcinogens are synergistic as a rule. However, various combinations of chemical carcinogens have been described which interact not even additively but in an antagonistic way. The aim of this review is to collect information of antagonistic interactions of occupational carcinogens obtained by epidemiologic and animal studies. In addition, appropriate in vitro studies with the genotoxic endpoints DNA-adducts and micronuclei are included. The toxicological mechanisms of antagonistic interactions, although speculative in some cases, are discussed.

Entities: Disease

Mesh：

Substances：

Year: 2005 PMID： 16228221 DOI： 10.1007/s00420-005-0045-8

Source DB: PubMed Journal: Int Arch Occup Environ Health ISSN： 0340-0131 Impact factor: 3.015

54 in total

1. On the protective action of certain polycyclic aromatic hydrocarbons against carcinogenesis by aminoazo dyes and 2-acetylaminofluorene.

Authors: E C MILLER; J A MILLER; R R BROWN; J C MACDONALD
Journal: Cancer Res Date: 1958-05 Impact factor: 12.701

2. The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene.

Authors: A H CONNEY; E C MILLER; J A MILLER
Journal: Cancer Res Date: 1956-06 Impact factor: 12.701

9. Modulating effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on skin carcinogenesis initiated by the weak inducer 7,12-dimethylbenz(a)anthracene.

Authors: P Lesca; N Perrot; B Peryt
Journal: Drug Metabol Drug Interact Date: 1994

10. Effects of cigarette smoke and disulfiram on tumorigenicity and clastogenicity of ethyl carbamate in mice.

Authors: R M Balansky
Journal: Cancer Lett Date: 1995-07-20 Impact factor: 8.679

1 in total

1. Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5- f ]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens.

Authors: Min Wei; Anna Kakehashi; Shotaro Yamano; Seiko Tamano; Tomoyuki Shirai; Hideki Wanibuchi; Shoji Fukushima
Journal: J Toxicol Pathol Date: 2012-10-01 Impact factor: 1.628

1 in total

Antagonistic combinations of occupational carcinogens.

1. On the protective action of certain polycyclic aromatic hydrocarbons against carcinogenesis by aminoazo dyes and 2-acetylaminofluorene.

2. The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene.

3. Some drinking-water disinfectants and contaminants, including arsenic.

4. The effect of pentachlorophenol on DNA adduct formation in p53 wild-type and knockout mice exposed to benzo[a]pyrene.

5. Dimethylbenzanthracene-induced mammary tumors in rats: inhibition by DDT.

6. The cigarette factor in lung cancer due to chloromethyl ethers.

7. Antagonistic interactions of an arsenic-containing mixture in a multiple organ carcinogenicity bioassay.

Review 8. Short- and long-term morbidity and mortality in the population exposed to dioxin after the "Seveso accident".

9. Modulating effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on skin carcinogenesis initiated by the weak inducer 7,12-dimethylbenz(a)anthracene.

10. Effects of cigarette smoke and disulfiram on tumorigenicity and clastogenicity of ethyl carbamate in mice.

1. Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5- f ]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens.