Literature DB >> 16228007

A minimal domain responsible for Munc13 activity.

Jayeeta Basu1, Nan Shen, Irina Dulubova, Jun Lu, Rong Guan, Oleg Guryev, Nick V Grishin, Christian Rosenmund, Josep Rizo.   

Abstract

Munc13 proteins are essential in neurotransmitter release, controlling the priming of synaptic vesicles to a release-ready state. The sequences responsible for this priming activity are unknown. Here we identify a large alpha-helical domain of mammalian Munc13-1 that is autonomously folded and is sufficient to rescue the total arrest in neurotransmitter release observed in hippocampal neurons lacking Munc13s.

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Year:  2005        PMID： 16228007     DOI： 10.1038/nsmb1001

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  99 in total

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4.  The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors.

Authors:  Wei Li; Cong Ma; Rong Guan; Yibin Xu; Diana R Tomchick; Josep Rizo
Journal:  Structure       Date:  2011-10-12       Impact factor: 5.006

5.  Resveratrol inhibits phorbol ester-induced membrane translocation of presynaptic Munc13-1.

Authors:  Satyabrata Pany; Anamitra Ghosh; Youngki You; Nga Nguyen; Joydip Das
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6.  Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution.

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Review 7.  The Ca(2+)-dependent activator protein for secretion CAPS: do I dock or do I prime?

Authors:  David R Stevens; Jens Rettig
Journal:  Mol Neurobiol       Date:  2009-01-23       Impact factor: 5.590

8.  Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.

Authors:  Mathias A Böhme; Christina Beis; Suneel Reddy-Alla; Eric Reynolds; Malou M Mampell; Andreas T Grasskamp; Janine Lützkendorf; Dominique Dufour Bergeron; Jan H Driller; Husam Babikir; Fabian Göttfert; Iain M Robinson; Cahir J O'Kane; Stefan W Hell; Markus C Wahl; Ulrich Stelzl; Bernhard Loll; Alexander M Walter; Stephan J Sigrist
Journal:  Nat Neurosci       Date:  2016-08-15       Impact factor: 24.884

9.  Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release.

Authors:  Cong Ma; Lijing Su; Alpay B Seven; Yibin Xu; Josep Rizo
Journal:  Science       Date:  2012-12-20       Impact factor: 47.728

10.  Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity.

Authors:  Fernando Rodríguez-Castañeda; Mitcheell Maestre-Martínez; Nicolas Coudevylle; Kalina Dimova; Harald Junge; Noa Lipstein; Donghan Lee; Stefan Becker; Nils Brose; Olaf Jahn; Teresa Carlomagno; Christian Griesinger
Journal:  EMBO J       Date:  2009-12-10       Impact factor: 11.598
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