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Literature DB >> 16227799

Inhibition of neutrophil function by the Kaposi's sarcoma-associated herpesvirus vOX2 protein.

S A Rahim Rezaee¹, J Alastair Gracie, Iain B McInnes, David J Blackbourn.

Abstract

Kaposi's sarcoma is multifactorial, involving Kaposi's sarcoma-associated herpesvirus (KSHV) infection and immune dysfunction. A KSHV protein (vOX2), fused with the Fc domain of human immunoglobulin G1 to create vOX2:Fc, suppressed neutrophil oxidative burst and inhibited the production of pro-inflammatory chemokines (IL-8 and monocyte chemoattractant protein 1) by monocyte/macrophage cells. vOX2:Fc suppressed the acute inflammatory response in mice in which neutrophil-mediated inflammation was induced by carrageenan. The data suggest that vOX2 can contribute to immune dysfunction and could have anti-inflammatory therapeutic potential.

Entities: Chemical Disease Gene Species

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Year: 2005 PMID： 16227799 DOI： 10.1097/01.aids.0000189849.75699.46

Source DB: PubMed Journal: AIDS ISSN： 0269-9370 Impact factor: 4.177

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Cited

19 in total

Review 1. Immune evasion by Kaposi's sarcoma-associated herpesvirus.

Authors: Hye-Ra Lee; Stacy Lee; Preet M Chaudhary; Parkash Gill; Jae U Jung
Journal: Future Microbiol Date: 2010-09 Impact factor: 3.165

Review 2. Kaposi sarcoma-associated herpesvirus: immunobiology, oncogenesis, and therapy.

Authors: Dirk P Dittmer; Blossom Damania
Journal: J Clin Invest Date: 2016-09-01 Impact factor: 14.808

3. Membrane-associated and secreted forms of the Rhesus macaque rhadinovirus-encoded CD200 homologue and cellular CD200 demonstrate differential effects on Rhesus Macaque CD200 Receptor signaling and regulation of myeloid cell activation.

Authors: Ryan D Estep; Aparna N Govindan; Kristin Fitzpatrick; Tiffany C Blair; S A Rahim Rezaee; David J Blackbourn; Scott W Wong
Journal: J Virol Date: 2020-12-16 Impact factor: 5.103

4. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65.

Authors: Xiaofan Li; Deguang Liang; Xianzhi Lin; Erle S Robertson; Ke Lan
Journal: J Virol Date: 2011-06-22 Impact factor: 5.103

5. Suppression of antigen-specific T cell responses by the Kaposi's sarcoma-associated herpesvirus viral OX2 protein and its cellular orthologue, CD200.

Authors: Karen Misstear; Simon A Chanas; S A Rahim Rezaee; Rachel Colman; Laura L Quinn; Heather M Long; Oliver Goodyear; Janet M Lord; Andrew D Hislop; David J Blackbourn
Journal: J Virol Date: 2012-04-04 Impact factor: 5.103

Review 6. Kaposi sarcoma.

Authors: Ethel Cesarman; Blossom Damania; Susan E Krown; Jeffrey Martin; Mark Bower; Denise Whitby
Journal: Nat Rev Dis Primers Date: 2019-01-31 Impact factor: 52.329

7. Pivotal advance: Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded microRNA specifically induce IL-6 and IL-10 secretion by macrophages and monocytes.

Authors: Zhiqiang Qin; Patricia Kearney; Karlie Plaisance; Chris H Parsons
Journal: J Leukoc Biol Date: 2010-01 Impact factor: 4.962