| Literature DB >> 16227700 |
Aurore Caqueret1, Chun Yang, Sabine Duplan, Francine Boucher, Jacques L Michaud.
Abstract
The hypothalamus is a critical integrator of several homeostatic processes that are required for the survival of vertebrates. Disruption of the development of the hypothalamus thus has the potential of perturbing important physiological processes with lifelong consequences. We review current knowledge about how cell types are specified and circuits are formed within the developing hypothalamus. We emphasize the potential clinical impact of the perturbations of these pathways using the regulation of energy balance as a model. We predict that disruption of hypothalamic development is a common, previously unsuspected cause of disorders of homeostatic processes such as obesity and high blood pressure. (c) 2005 S. Karger AG, Basel.Entities:
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Year: 2005 PMID： 16227700 DOI： 10.1159/000088977
Source DB: PubMed Journal: Horm Res ISSN： 0301-0163