BACKGROUND: The role of transforming growth factor-beta1 (TGF-beta1) in chronic obstructive pulmonary disease is still controversial, but it has been proposed that it may protect from mucus hypersecretion since it is able to downregulate mucin production. A study was undertaken to investigate the expression of TGF-beta1 and its type II receptor (TGF-beta RII) in the bronchial glands of smokers with COPD. METHODS: The expression of TGF-beta(1) and TGF-beta RII were examined immunohistochemically in the bronchial glands of 24 smokers undergoing lung resection for solitary peripheral nodules: 12 with airflow limitation (smokers with COPD) and 12 with normal lung function. RESULTS: The expression of TGF-beta1 in bronchial glands was similar in the two groups of subjects while that of TGF-beta RII was lower in smokers with COPD than in smokers with normal lung function (p=0.004). TGF-beta RII expression was inversely correlated with the values of Reid's index, a measure of gland size (p=0.02, r=-0.50). CONCLUSIONS: In the bronchial glands of smokers with COPD there is decreased expression of TGF-beta RII which is associated with bronchial gland enlargement. These findings support the view that the absence of TGF-beta signalling may induce structural changes in the bronchial glands which, in turn, may promote mucus hypersecretion.
BACKGROUND: The role of transforming growth factor-beta1 (TGF-beta1) in chronic obstructive pulmonary disease is still controversial, but it has been proposed that it may protect from mucus hypersecretion since it is able to downregulate mucin production. A study was undertaken to investigate the expression of TGF-beta1 and its type II receptor (TGF-beta RII) in the bronchial glands of smokers with COPD. METHODS: The expression of TGF-beta(1) and TGF-beta RII were examined immunohistochemically in the bronchial glands of 24 smokers undergoing lung resection for solitary peripheral nodules: 12 with airflow limitation (smokers with COPD) and 12 with normal lung function. RESULTS: The expression of TGF-beta1 in bronchial glands was similar in the two groups of subjects while that of TGF-beta RII was lower in smokers with COPD than in smokers with normal lung function (p=0.004). TGF-beta RII expression was inversely correlated with the values of Reid's index, a measure of gland size (p=0.02, r=-0.50). CONCLUSIONS: In the bronchial glands of smokers with COPD there is decreased expression of TGF-beta RII which is associated with bronchial gland enlargement. These findings support the view that the absence of TGF-beta signalling may induce structural changes in the bronchial glands which, in turn, may promote mucus hypersecretion.
Authors: H Takizawa; M Tanaka; K Takami; T Ohtoshi; K Ito; M Satoh; Y Okada; F Yamasawa; K Nakahara; A Umeda Journal: Am J Respir Crit Care Med Date: 2001-05 Impact factor: 21.405
Authors: Anja Sterner-Kock; Irmgard S Thorey; Katri Koli; Frank Wempe; Jürgen Otte; Thorsten Bangsow; Katharina Kuhlmeier; Thomas Kirchner; Shenchu Jin; Jorma Keski-Oja; Harald von Melchner Journal: Genes Dev Date: 2002-09-01 Impact factor: 11.361
Authors: David G Morris; Xiaozhu Huang; Naftali Kaminski; Yanli Wang; Steven D Shapiro; Gregory Dolganov; Adam Glick; Dean Sheppard Journal: Nature Date: 2003-03-13 Impact factor: 49.962
Authors: Bing Xu; Hui Chen; Wei Xu; Wenming Zhang; Sue Buckley; Song Guo Zheng; David Warburton; Martin Kolb; Jack Gauldie; Wei Shi Journal: Am J Physiol Lung Cell Mol Physiol Date: 2012-05-18 Impact factor: 5.464
Authors: Lisa Heitmann; Reena Rani; Lucas Dawson; Charles Perkins; Yanfen Yang; Jordan Downey; Christoph Hölscher; De'Broski R Herbert Journal: Am J Pathol Date: 2012-09 Impact factor: 4.307
Authors: Laura L Hoang; Yen P Nguyen; Rayza Aspeé; Sarah J Bolton; Yi-Hsin Shen; Lei Wang; Nicholas J Kenyon; Suzette Smiley-Jewell; Kent E Pinkerton Journal: Am J Respir Cell Mol Biol Date: 2016-06 Impact factor: 6.914
Authors: Dandi Qiao; Asher Ameli; Dmitry Prokopenko; Han Chen; Alvin T Kho; Margaret M Parker; Jarrett Morrow; Brian D Hobbs; Yanhong Liu; Terri H Beaty; James D Crapo; Kathleen C Barnes; Deborah A Nickerson; Michael Bamshad; Craig P Hersh; David A Lomas; Alvar Agusti; Barry J Make; Peter M A Calverley; Claudio F Donner; Emiel F Wouters; Jørgen Vestbo; Peter D Paré; Robert D Levy; Stephen I Rennard; Ruth Tal-Singer; Margaret R Spitz; Amitabh Sharma; Ingo Ruczinski; Christoph Lange; Edwin K Silverman; Michael H Cho Journal: Hum Mol Genet Date: 2018-11-01 Impact factor: 5.121