| Literature DB >> 16226463 |
Abstract
Recent reports have demonstrated that small duplex RNAs mediate recognition of chromosomal DNA and inhibit transcription within mammalian cells. Key unresolved issues include whether RNAs directly bind to DNA, the identification of the mechanism(s) that convert chromosome recognition into gene silencing and whether naturally occurring antigene RNAs (agRNAs) exist.Entities:
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Year: 2005 PMID: 16226463 DOI: 10.1016/j.tibs.2005.09.007
Source DB: PubMed Journal: Trends Biochem Sci ISSN: 0968-0004 Impact factor: 13.807