STUDY OBJECTIVES: To evaluate the rapid urine antigen tests, including a new rapid immunochromatographic test (ICT) for the detection of the Streptococcus pneumoniae antigen and an enzyme immunoassay (EIA) for the detection of the Legionella antigen, in order to improve the diagnosis of community-acquired pneumonia (CAP) in adults. DESIGN: Prospective study. SETTING: A tertiary hospital in Spain. PATIENTS: We consecutively recruited 107 adults with CAP evaluated at our hospital. INTERVENTIONS: The analyses included blood and sputum cultures, pleural fluid culture (if present) and serologic studies. The detection of the Legionella pneumophila urinary antigen was performed by EIA, and the detection of S. pneumoniae antigen in urine samples was performed by counterimmunoelectrophoresis (CIE) and a rapid ICT. RESULTS: Using conventional microbiologic tests we succeeded in performing the etiologic diagnosis of 39 out of the 107 cases (36.4%). The inclusion of rapid antigen detection techniques increased the percentage of diagnosis to 54.2%, which represents a total increase of 17.8% (P=0.034). CONCLUSIONS: The data obtained in this study indicate that rapid urine antigen tests are very useful to determine CAP etiology in adults and, consequently, to quickly identify a group of patients in whom narrow spectrum antibiotics may be used.
STUDY OBJECTIVES: To evaluate the rapid urine antigen tests, including a new rapid immunochromatographic test (ICT) for the detection of the Streptococcus pneumoniae antigen and an enzyme immunoassay (EIA) for the detection of the Legionella antigen, in order to improve the diagnosis of community-acquired pneumonia (CAP) in adults. DESIGN: Prospective study. SETTING: A tertiary hospital in Spain. PATIENTS: We consecutively recruited 107 adults with CAP evaluated at our hospital. INTERVENTIONS: The analyses included blood and sputum cultures, pleural fluid culture (if present) and serologic studies. The detection of the Legionella pneumophila urinary antigen was performed by EIA, and the detection of S. pneumoniae antigen in urine samples was performed by counterimmunoelectrophoresis (CIE) and a rapid ICT. RESULTS: Using conventional microbiologic tests we succeeded in performing the etiologic diagnosis of 39 out of the 107 cases (36.4%). The inclusion of rapid antigen detection techniques increased the percentage of diagnosis to 54.2%, which represents a total increase of 17.8% (P=0.034). CONCLUSIONS: The data obtained in this study indicate that rapid urine antigen tests are very useful to determine CAP etiology in adults and, consequently, to quickly identify a group of patients in whom narrow spectrum antibiotics may be used.
Authors: F Andreo; C Prat; J Ruiz-Manzano; L Lores; S Blanco; M A Cuesta; M Giménez; J Domínguez Journal: Eur J Clin Microbiol Infect Dis Date: 2008-10-02 Impact factor: 3.267
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Authors: A Lacoma; N Rodríguez; C Prat; J Ruiz-Manzano; F Andreo; A Ramírez; A Bas; M Pérez; V Ausina; J Domínguez Journal: Eur J Clin Microbiol Infect Dis Date: 2011-08-26 Impact factor: 3.267
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Authors: David R Boulware; Charles L Daley; Cynthia Merrifield; Philip C Hopewell; Edward N Janoff Journal: J Infect Date: 2007-08-10 Impact factor: 6.072
Authors: Maria A Said; Hope L Johnson; Bareng A S Nonyane; Maria Deloria-Knoll; Katherine L O'Brien; Felipe Andreo; Bojana Beovic; Silvia Blanco; Wim G Boersma; David R Boulware; Jay C Butler; Jordi Carratalà; Feng-Yee Chang; Patrick G P Charles; Alejandro A Diaz; Jose Domínguez; Naomi Ehara; Henrik Endeman; Vicenç Falcó; Miquel Falguera; Kiyoyasu Fukushima; Carolina Garcia-Vidal; Daniel Genne; Igor A Guchev; Felix Gutierrez; Susanne S Hernes; Andy I M Hoepelman; Ulla Hohenthal; Niclas Johansson; Vitezslav Kolek; Roman S Kozlov; Tsai-Ling Lauderdale; Ivana Mareković; Mar Masiá; Matta A Matta; Òscar Miró; David R Murdoch; Eric Nuermberger; Richard Paolini; Rafael Perelló; Dominic Snijders; Vanda Plečko; Roger Sordé; Kristoffer Strålin; Menno M van der Eerden; Angel Vila-Corcoles; James P Watt Journal: PLoS One Date: 2013-04-02 Impact factor: 3.240