Literature DB >> 16226353

Polyamidoamine dendrimers used as solubility enhancers of ketoprofen.

Cheng Yiyun1, Xu Tongwen, Fu Rongqiang.   

Abstract

Ketoprofen is a non-steroidal anti-inflammatory drug which is not freely soluble in water and creates gastrointestinal problems. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers to increase the solubility of ketoprofen. The effect of variables, such as pH condition, concentration and generation of dendrimer, has been investigated. The experimental results showed that the solubility of ketoprofen in the dendrimer solutions was proportional to dendrimer concentration. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of ketoprofen.

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Year:  2005        PMID： 16226353     DOI： 10.1016/j.ejmech.2005.08.002

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  12 in total

1.  Dendrimers as drug delivery vehicles: non-covalent interactions of bioactive compounds with dendrimers.

Authors:  Hannah L Crampton; Eric E Simanek
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2.  Evaluation of poly(amidoamine) dendrimers as potential carriers of iminodiacetic derivatives using solubility studies and 2D-NOESY NMR spectroscopy.

Authors:  Magdalena Markowicz; Paweł Szymański; Marcin Ciszewski; Arkadiusz Kłys; Elżbieta Mikiciuk-Olasik
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4.  High-Resolution Imaging of Dendrimers Used in Drug Delivery via Scanning Probe Microscopy.

Authors:  Lifang Shi; Christopher J Fleming; Shawn L Riechers; Nai-Ning Yin; Juntao Luo; Kit S Lam; Gang-Yu Liu
Journal:  J Drug Deliv       Date:  2011-06-13

5.  The polyamidoamine-mediated inhibition of bcl-2 by small hairpin RNA to induce apoptosis in human lens epithelial cells.

Authors:  Xin-Hua Wu; Yi Lu; Yan-Wen Fang; Yong-Xiang Jiang
Journal:  Mol Vis       Date:  2012-01-12       Impact factor: 2.367

6.  Prolonged drug delivery system of an antifungal drug by association with polyamidoamine dendrimers.

Authors:  Jobin Jose; R Narayana Charyulu
Journal:  Int J Pharm Investig       Date:  2016 Apr-Jun

Review 7.  Understanding peroral absorption: regulatory aspects and contemporary approaches to tackling solubility and permeability hurdles.

Authors:  Prachi B Shekhawat; Varsha B Pokharkar
Journal:  Acta Pharm Sin B       Date:  2016-11-02       Impact factor: 11.413

Review 8.  Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules.

Authors:  Sonam Choudhary; Lokesh Gupta; Sarita Rani; Kaushalkumar Dave; Umesh Gupta
Journal:  Front Pharmacol       Date:  2017-05-16       Impact factor: 5.810

9.  Solubility of aceclofenac in polyamidoamine dendrimer solutions.

Authors:  Jaydeep Patel; Kevin Garala; Biswajit Basu; Mihir Raval; Abhay Dharamsi
Journal:  Int J Pharm Investig       Date:  2011-07

10.  Improvement in solubility of poor water-soluble drugs by solid dispersion.

Authors:  Swati Sareen; George Mathew; Lincy Joseph
Journal:  Int J Pharm Investig       Date:  2012-01
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