Literature DB >> 16226245

Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -nonpreferring rats.

M Paola Castelli1, Fabio Pibiri, A Paola Piras, Giovanni Carboni, Alessandro Orrù, Gian Luigi Gessa, Mauro A M Carai, Giancarlo Colombo.   

Abstract

The function of the gamma-aminobutyric acid(B) (GABAB) receptor, measured as baclofen-stimulated [35S]GTPgammaS binding, was evaluated in some brain regions of Sardinian alcohol-preferring (sP) and -nonpreferring (sNP) rats. EC50 value of baclofen-stimulated [35S]GTPgammaS in limbic areas was approximately 125% higher in alcohol-naive sP than sNP rats; voluntarily consumed alcohol reduced the EC50 value to a level similar to that of alcohol-naive sNP rats. These results suggest the presence of a genetically determined lower function of the GABAB receptor in limbic areas of sP than sNP rats; this differential functioning of the GABAB receptor may contribute to the opposite preference for alcohol in these rat lines.

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Year:  2005        PMID： 16226245     DOI： 10.1016/j.ejphar.2005.09.011

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  Acute withdrawal from chronic escalating-dose binge cocaine administration alters kappa opioid receptor stimulation of [35S] guanosine 5'-O-[gamma-thio]triphosphate acid binding in the rat ventral tegmental area.

Authors:  A P Piras; Y Zhou; S D Schlussman; A Ho; M J Kreek
Journal:  Neuroscience       Date:  2010-05-07       Impact factor: 3.590

2.  GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol.

Authors:  Sarah E Holstein; Tamara J Phillips
Journal:  Pharmacol Biochem Behav       Date:  2006-12-11       Impact factor: 3.533

Review 3.  Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.

Authors:  Richard L Bell; Helen J K Sable; Giancarlo Colombo; Petri Hyytia; Zachary A Rodd; Lawrence Lumeng
Journal:  Pharmacol Biochem Behav       Date:  2012-07-25       Impact factor: 3.533

4.  The GABAB receptor positive allosteric modulator ASP8062 reduces operant alcohol self-administration in male and female Sprague Dawley rats.

Authors:  Colin N Haile; Benjamin A Carper; Tracy L Nolen; Therese A Kosten
Journal:  Psychopharmacology (Berl)       Date:  2021-07-06       Impact factor: 4.530

5.  GABAB receptor activation attenuates the stimulant but not mesolimbic dopamine response to ethanol in FAST mice.

Authors:  Sarah E Holstein; Na Li; Amy J Eshleman; Tamara J Phillips
Journal:  Behav Brain Res       Date:  2012-09-13       Impact factor: 3.332

6.  Ethanol induces stronger dopamine release in nucleus accumbens (shell) of alcohol-preferring (bibulous) than in alcohol-avoiding (abstainer) rats.

Authors:  Diego Bustamante; Maria Elena Quintanilla; Lutske Tampier; Victor Gonzalez-Lira; Yedy Israel; Mario Herrera-Marschitz
Journal:  Eur J Pharmacol       Date:  2008-06-24       Impact factor: 4.432

7.  Cellular and behavioral interactions of gabapentin with alcohol dependence.

Authors:  Marisa Roberto; Nicholas W Gilpin; Laura E O'Dell; Maureen T Cruz; Andrew C Morse; George R Siggins; George F Koob
Journal:  J Neurosci       Date:  2008-05-28       Impact factor: 6.167

8.  Baclofen and naltrexone, but not N-acetylcysteine, affect voluntary alcohol drinking in rats regardless of individual levels of alcohol intake.

Authors:  A Maryse Minnaard; Geert M J Ramakers; Louk J M J Vanderschuren; Heidi M B Lesscher
Journal:  Behav Pharmacol       Date:  2021-04-01       Impact factor: 2.277
  8 in total

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