Literature DB >> 16224607

Clinical subtypes of obsessive-compulsive disorder based on the presence of checking and washing compulsions.

Leonardo F Fontenelle1, Mauro V Mendlowicz, Marcio Versiani.   

Abstract

OBJECTIVE: We aimed at examining the utility of checking and washing compulsions as markers of valid subtypes of obsessive-compulsive disorder (OCD).
METHODS: One hundred and six patients with obsessive-compulsive disorder were evaluated with a socio-demographic and clinical questionnaire, the Structured Clinical Interview for DSM-IV, the Yale-Brown Obsessive-Compulsive Scale, the Clinical Global Impression, the Beck Depression Inventory, the Hamilton Rating Scale for Depression, and the Global Assessment of Functioning. These individuals were allocated in one of four subgroups [checkers (OCD-Ch; n = 20), washers (OCD-Wa; n = 13), checkers and washers (OCD-CW; n = 48), and non-checkers and non-washers (OCD non-CW = 25)] on the basis of the presence and the clinical relevance of checking and/or washing compulsive behaviors across their lifetime. Socio-demographic and clinical variables were compared and contrasted between the groups by means of ANOVA followed by post-hoc Least Significant Difference or Dunnett's tests for continuous variables and chi-square tests followed by partitioned chi-square tests for categorical variables.
RESULTS: OCD-Ch and OCD-Wa did not differ on most demographic and clinical features, the only exception being the number of different types of obsessions, which were significantly higher in the former group. The OCD-CW group was more likely to exhibit an insidious onset of obsessive-compulsive symptoms, to manifest itself as a mixed subtype of obsessive-compulsive disorder and to display obsessions with contamination themes. On the other hand, the OCD non-CW group was more likely to exhibit an acute onset, a shorter duration of illness, obsessions with religious themes, an episodic course, and less severe obsessive-compulsive symptoms.
CONCLUSIONS: In our sample, the probing of the presence of checking and/or washing compulsions has provided significant empirical support to establish valid subtypes of obsessive-compulsive disorder.

Entities:  

Mesh:

Year:  2005        PMID: 16224607     DOI: 10.1590/s1516-44462005000300008

Source DB:  PubMed          Journal:  Braz J Psychiatry        ISSN: 1516-4446            Impact factor:   2.697


  5 in total

1.  Strain and sex based characterization of behavioral expressions in non-induced compulsive-like mice.

Authors:  Swarup Mitra; Cristiane P Bastos; Savanna Chesworth; Cheryl Frye; Abel Bult-Ito
Journal:  Physiol Behav       Date:  2016-11-10

2.  Ovarian Sex Hormones Modulate Compulsive, Affective and Cognitive Functions in A Non-Induced Mouse Model of Obsessive-Compulsive Disorder.

Authors:  Swarup Mitra; Cristiane P Bastos; Katherine Bates; Grace S Pereira; Abel Bult-Ito
Journal:  Front Behav Neurosci       Date:  2016-11-09       Impact factor: 3.558

3.  Fluoxetine Regulates Ig Kappa Chain C Region Expression Levels in the Serum of Obsessive-Compulsive Disorder Patients: A proteomic Approach.

Authors:  Mona Zamanian Azodi; Mostafa Rezaei Tavirani; Afsaneh Arefi Oskouie; Mostafa Hamdieh; Mohammad Kamran Derakhshan; Alireza Ahmadzadeh; Farid Zayeri; Naser Nejadi; Majid Rezaei Tavirani; Vahid Mansouri; Mohammad Rostami-Nejad; Reza Vafaee
Journal:  Iran J Pharm Res       Date:  2017       Impact factor: 1.696

4.  A cross-species assessment of behavioral flexibility in compulsive disorders.

Authors:  Nabil Benzina; Karim N'Diaye; Antoine Pelissolo; Luc Mallet; Eric Burguière
Journal:  Commun Biol       Date:  2021-01-21

Review 5.  Bidirectional Behavioral Selection in Mice: A Novel Pre-clinical Approach to Examining Compulsivity.

Authors:  Swarup Mitra; Abel Bult-Ito
Journal:  Front Psychiatry       Date:  2021-09-08       Impact factor: 4.157

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.