BACKGROUND: Public health policy to prevent iron deficiency through food fortification or other measures may be disadvantageous to people with hereditary hemochromatosis. METHODS: From a cohort of U.K. women, 2531 women were typed for C282Y and H63D mutations in the hemochromatosis gene. These women completed food frequency questionnaires and provided blood for iron status. RESULTS: C282Y homozygotes (n=31) had serum ferritin concentrations 2.4 times higher (95% confidence interval=1.9-3.1) than wild types (n=1774), but heterozygotes (n=726) were not different from wild types. H63D genotype had no effect on its own. The effect of heme iron intake (from meat, fish, and poultry) was 2.0 times greater (1.2-3.2) on C282Y homozygotes than other groups. Nonheme iron had little effect. CONCLUSIONS: There may be scope for dietary intervention in women homozygous for the C282Y mutation. C282Y heterozygotes and H63D homozygotes and heterozygotes have similar serum ferritin concentrations to wild type and need not reduce their meat intake other than as part of a normal healthy diet.
BACKGROUND: Public health policy to prevent iron deficiency through food fortification or other measures may be disadvantageous to people with hereditary hemochromatosis. METHODS: From a cohort of U.K. women, 2531 women were typed for C282Y and H63D mutations in the hemochromatosis gene. These women completed food frequency questionnaires and provided blood for iron status. RESULTS:C282Y homozygotes (n=31) had serum ferritin concentrations 2.4 times higher (95% confidence interval=1.9-3.1) than wild types (n=1774), but heterozygotes (n=726) were not different from wild types. H63D genotype had no effect on its own. The effect of hemeiron intake (from meat, fish, and poultry) was 2.0 times greater (1.2-3.2) on C282Y homozygotes than other groups. Nonheme iron had little effect. CONCLUSIONS: There may be scope for dietary intervention in women homozygous for the C282Y mutation. C282Y heterozygotes and H63D homozygotes and heterozygotes have similar serum ferritin concentrations to wild type and need not reduce their meat intake other than as part of a normal healthy diet.
Authors: Victor R Gordeuk; Laura Lovato; James Barton; Mara Vitolins; Gordon McLaren; Ronald Acton; Christine McLaren; Emily Harris; Mark Speechley; John H Eckfeldt; Sharmin Diaz; Phyliss Sholinsky; Paul Adams Journal: Can J Gastroenterol Date: 2012-06 Impact factor: 3.522
Authors: Janet E Cade; Victoria J Burley; Nisreen A Alwan; Jayne Hutchinson; Neil Hancock; Michelle A Morris; Diane E Threapleton; Darren C Greenwood Journal: Int J Epidemiol Date: 2017-04-01 Impact factor: 7.196
Authors: Simone Buerkli; Laura Salvioni; Natalie Koller; Christophe Zeder; Maria José Teles; Graça Porto; Jana Helena Habermann; Irina Léa Dubach; Florence Vallelian; Beat M Frey; Diego Moretti; Jeannine Baumgartner; Michael B Zimmermann Journal: Eur J Nutr Date: 2022-03-23 Impact factor: 4.865