Literature DB >> 16221889

Phosphatidylinositol 4,5-bisphosphate anchors cytosolic group IVA phospholipase A2 to perinuclear membranes and decreases its calcium requirement for translocation in live cells.

Javier Casas1, Miguel A Gijón, Ana G Vigo, Mariano Sánchez Crespo, Jesús Balsinde, María A Balboa.   

Abstract

The eicosanoids are centrally involved in the onset and resolution of inflammatory processes. A key enzyme in eicosanoid biosynthesis during inflammation is group IVA phospholipase A2 (also known as cytosolic phospholipase A2alpha, cPLA2alpha). This enzyme is responsible for generating free arachidonic acid from membrane phospholipids. cPLA2alpha translocates to perinuclear membranes shortly after cell activation, in a process that is governed by the increased availability of intracellular Ca2+. However, cPLA2alpha also catalyzes membrane phospholipid hydrolysis in response to agonists that do not mobilize intracellular Ca2+. How cPLA2alpha interacts with membranes under these conditions is a major, still unresolved issue. Here, we report that phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] promotes translocation of cPLA2alpha to perinuclear membranes of intact cells in a manner that is independent of rises in the intracellular Ca2+ concentration. PtdIns(4,5)P2 anchors the enzyme to perinuclear membranes and allows for a proper interaction with its phospholipid substrate to release arachidonic acid.

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Year:  2005        PMID： 16221889      PMCID： PMC1345655          DOI： 10.1091/mbc.e05-06-0545

Source DB:  PubMed          Journal:  Mol Biol Cell        ISSN： 1059-1524            Impact factor:   4.138


  30 in total

Review 1.  Recent advances in the regulation of cytosolic phospholipase A(2).

Authors:  M A Gijón; D M Spencer; C C Leslie
Journal:  Adv Enzyme Regul       Date:  2000

2.  Identification of a cellular protein that functionally interacts with the C2 domain of cytosolic phospholipase A(2)alpha.

Authors:  Y Nakatani; T Tanioka; S Sunaga; M Murakami; I Kudo
Journal:  J Biol Chem       Date:  2000-01-14       Impact factor: 5.157

3.  PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production.

Authors:  A M Sheridan; T Force; H J Yoon; E O'Leary; G Choukroun; M R Taheri; J V Bonventre
Journal:  Mol Cell Biol       Date:  2001-07       Impact factor: 4.272

4.  Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels.

Authors:  J Balsinde; M A Balboa; W H Li; J Llopis; E A Dennis
Journal:  J Immunol       Date:  2000-05-15       Impact factor: 5.422

5.  Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriers.

Authors:  S Ozaki; D B DeWald; J C Shope; J Chen; G D Prestwich
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-10       Impact factor: 11.205

Review 6.  The expanding superfamily of phospholipase A(2) enzymes: classification and characterization.

Authors:  D A Six; E A Dennis
Journal:  Biochim Biophys Acta       Date:  2000-10-31

7.  Cytosolic phospholipase A2 is required for macrophage arachidonic acid release by agonists that Do and Do not mobilize calcium. Novel role of mitogen-activated protein kinase pathways in cytosolic phospholipase A2 regulation.

Authors:  M A Gijón; D M Spencer; A R Siddiqi; J V Bonventre; C C Leslie
Journal:  J Biol Chem       Date:  2000-06-30       Impact factor: 5.157

8.  Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine.

Authors:  Preeti Subramanian; Robert V Stahelin; Zdzislaw Szulc; Alicja Bielawska; Wonhwa Cho; Charles E Chalfant
Journal:  J Biol Chem       Date:  2005-03-01       Impact factor: 5.157

9.  Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism.

Authors:  A Dessen; J Tang; H Schmidt; M Stahl; J D Clark; J Seehra; W S Somers
Journal:  Cell       Date:  1999-04-30       Impact factor: 41.582

10.  Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2.

Authors:  O Perisic; H F Paterson; G Mosedale; S Lara-González; R L Williams
Journal:  J Biol Chem       Date:  1999-05-21       Impact factor: 5.157
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  30 in total

Review 1.  Cytosolic phospholipase A₂: physiological function and role in disease.

Authors:  Christina C Leslie
Journal:  J Lipid Res       Date:  2015-04-02       Impact factor: 5.922

2.  JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2.

Authors:  Albert Gubern; Miquel Barceló-Torns; David Barneda; José M López; Roser Masgrau; Fernando Picatoste; Charles E Chalfant; Jesús Balsinde; María A Balboa; Enrique Claro
Journal:  J Biol Chem       Date:  2009-09-24       Impact factor: 5.157

3.  The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.

Authors:  Clara Meana; Ginesa García-Rostán; Lucía Peña; Gema Lordén; África Cubero; Antonio Orduña; Balázs Győrffy; Jesús Balsinde; María A Balboa
Journal:  JCI Insight       Date:  2018-09-20

4.  Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function.

Authors:  Dawn E Tucker; Moumita Ghosh; Farideh Ghomashchi; Robyn Loper; Saritha Suram; Bonnie St John; Milena Girotti; James G Bollinger; Michael H Gelb; Christina C Leslie
Journal:  J Biol Chem       Date:  2009-01-28       Impact factor: 5.157

5.  TLR-4 mediated group IVA phospholipase A(2) activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent.

Authors:  Andrej Grkovich; Aaron Armando; Oswald Quehenberger; Edward A Dennis
Journal:  Biochim Biophys Acta       Date:  2009-02-20

6.  The cationic cluster of group IVA phospholipase A2 (Lys488/Lys541/Lys543/Lys544) is involved in translocation of the enzyme to phagosomes in human macrophages.

Authors:  Javier Casas; Martín Valdearcos; José Pindado; Jesús Balsinde; María A Balboa
Journal:  J Lipid Res       Date:  2009-08-28       Impact factor: 5.922

7.  Low molecular weight hyaluronan activates cytosolic phospholipase A2α and eicosanoid production in monocytes and macrophages.

Authors:  Milena Sokolowska; Li-Yuan Chen; Michael Eberlein; Asuncion Martinez-Anton; Yueqin Liu; Sara Alsaaty; Hai-Yan Qi; Carolea Logun; Maureen Horton; James H Shelhamer
Journal:  J Biol Chem       Date:  2013-12-23       Impact factor: 5.157

8.  Occurrence and biological activity of palmitoleic acid isomers in phagocytic cells.

Authors:  Alma M Astudillo; Clara Meana; Carlos Guijas; Laura Pereira; Patricia Lebrero; María A Balboa; Jesús Balsinde
Journal:  J Lipid Res       Date:  2017-11-21       Impact factor: 5.922

9.  Ceramide 1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesis.

Authors:  Nadia F Lamour; Preeti Subramanian; Dayanjan S Wijesinghe; Robert V Stahelin; Joseph V Bonventre; Charles E Chalfant
Journal:  J Biol Chem       Date:  2009-07-23       Impact factor: 5.157

Review 10.  Phospholipases A2 and inflammatory responses in the central nervous system.

Authors:  Grace Y Sun; Phullara B Shelat; Michael B Jensen; Yan He; Albert Y Sun; Agnes Simonyi
Journal:  Neuromolecular Med       Date:  2009-10-24       Impact factor: 3.843
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