Literature DB >> 16220291

Novel transdermal photodynamic therapy using ATX-S10.Na(II) induces apoptosis of synovial fibroblasts and ameliorates collagen antibody-induced arthritis in mice.

S Miyazawa1, K Nishida, T Komiyama, Y Nakae, K Takeda, M Yorimitsu, A Kitamura, T Kunisada, A Ohtsuka, H Inoue.   

Abstract

We aimed to test the effect of transdermal photodynamic therapy (PDT) on synovial proliferation in vitro and in vivo, using a novel photosensitizer, ATX-S10.Na(II). Synovial fibroblasts were obtained from patients with RA (RASF). Cell viability with or without PDT was determined by MTT assay. Cell morphology was examined by light and transmission electron microscopy. DNA fragmentation was labeled by TUNEL stain. Collagen antibody-induced arthritis (CAIA) was induced in DBA/1 mice, and the effects of transdermal PDT were evaluated by clinical and histological examination. PDT showed drug concentration-dependent and laser dose-dependent cytotoxicity on RASF. TUNEL stain and TEM study revealed the induction of apoptotic cell death of RASF. Transdermal PDT significantly reduced clinical arthritis and synovial inflammation in this model of arthritis. These results suggest that transdermal PDT using ATX-S10.Na(II) might be a novel less invasive treatment strategy for small joint arthritis and tenosynovitis.

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Year:  2005        PMID： 16220291     DOI： 10.1007/s00296-005-0052-9

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  41 in total

1.  Dynamic observation of selective accumulation of a photosensitizer and its photodynamic effects in rat experimental choroidal neovascularization.

Authors:  T Hikichi; F Mori; S Nakajima; T A Takamiya; M Takeda; M Sasaki; Y Horikawa; A Yoshida
Journal:  Retina       Date:  2001       Impact factor: 4.256

2.  Photodynamic synovectomy using benzoporphyrin derivative in an antigen-induced arthritis model for rheumatoid arthritis.

Authors:  K B Trauner; R Gandour-Edwards; M Bamberg; S Shortkroff; C Sledge; T Hasan
Journal:  Photochem Photobiol       Date:  1998-01       Impact factor: 3.421

3.  Charcot's arthropathy of the shoulder following intraarticular corticosteroid injections.

Authors:  J R Parikh; J B Houpt; S Jacobs; B J Fernandes
Journal:  J Rheumatol       Date:  1993-05       Impact factor: 4.666

4.  Apoptosis of gastric cancer cell line MKN45 by photodynamic treatment with photofrin.

Authors:  Kenichiro Takahira; Munetaka Sano; Hajime Arai; Hiroyuki Hanai
Journal:  Lasers Med Sci       Date:  2004       Impact factor: 3.161

5.  Application of photodynamic therapy to the treatment of atherosclerotic plaques.

Authors:  G Tang; S Hyman; J H Schneider; S L Giannotta
Journal:  Neurosurgery       Date:  1993-03       Impact factor: 4.654

6.  Activation of two caspase cascades, caspase 8/3/6 and caspase 9/3/6, during photodynamic therapy using a novel photosensitizer, ATX-S10(Na), in normal human keratinocytes.

Authors:  Hidetoshi Takahashi; Yasuhiro Itoh; Yuki Miyauchi; Susumu Nakajima; Isao Sakata; Akemi Ishida-Yamamoto; Hajime Iizuka
Journal:  Arch Dermatol Res       Date:  2003-09-11       Impact factor: 3.017

7.  Photodynamic therapy as palliation for esophageal cancer: experience in 215 patients.

Authors:  Virginia R Litle; James D Luketich; Neil A Christie; Percival O Buenaventura; Miguel Alvelo-Rivera; James S McCaughan; Ninh T Nguyen; Hiran C Fernando
Journal:  Ann Thorac Surg       Date:  2003-11       Impact factor: 4.330

8.  Effect of NOS2 gene deficiency on the development of autoantibody mediated arthritis and subsequent articular cartilage degeneration.

Authors:  Hisayoshi Kato; Keiichiro Nishida; Aki Yoshida; Itsuro Takada; Cherie McCown; Masatsugu Matsuo; Takuro Murakami; Hajime Inoue
Journal:  J Rheumatol       Date:  2003-02       Impact factor: 4.666

9.  Elucidation of the relationship between synovitis and bone damage: a randomized magnetic resonance imaging study of individual joints in patients with early rheumatoid arthritis.

Authors:  Philip G Conaghan; Philip O'Connor; Dennis McGonagle; Paul Astin; Richard J Wakefield; Wayne W Gibbon; Mark Quinn; Zunaid Karim; Michael J Green; Susanna Proudman; John Isaacs; Paul Emery
Journal:  Arthritis Rheum       Date:  2003-01

10.  Photodynamic therapy for experimental tumors using ATX-S10(Na), a hydrophilic chlorin photosensitizer, and diode laser.

Authors:  M Mori; I Sakata; T Hirano; A Obana; S Nakajima; M Hikida; T Kumagai
Journal:  Jpn J Cancer Res       Date:  2000-07
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  3 in total

1.  Effects of the Sri Lankan medicinal plant, Salacia reticulata, in rheumatoid arthritis.

Authors:  Yuusuke Sekiguchi; Hiroshi Mano; Sachie Nakatani; Jun Shimizu; Masahiro Wada
Journal:  Genes Nutr       Date:  2009-09-02       Impact factor: 5.523

Review 2.  Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis.

Authors:  Kutty Selva Nandakumar; Rikard Holmdahl
Journal:  Arthritis Res Ther       Date:  2006       Impact factor: 5.156

3.  Evaluation of Ruthenium-Based Assemblies as Carriers of Photosensitizers to Treat Rheumatoid Arthritis by Photodynamic Therapy.

Authors:  Manuel Gallardo-Villagrán; Lucie Paulus; Jean-Louis Charissoux; Sylvain Sutour; Pascale Vergne-Salle; David Yannick Leger; Bertrand Liagre; Bruno Therrien
Journal:  Pharmaceutics       Date:  2021-12-07       Impact factor: 6.321
  3 in total

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