OBJECTIVES: Thyroid cancer risk has been previously associated with increased age at first pregnancy and history of miscarriage. Occupational risk factors for thyroid cancer, with the exception of radioactive iodine, have not been well investigated. We conducted a case-cohort study nested in a cohort of 267,400 female textile workers in Shanghai, China, who had been followed for cancer incidence during 1989-1998. METHODS: The analysis included 130 incident thyroid cases and 3,187 subcohort non-cases. Reproductive history was determined by questionnaire at baseline. Historical exposures were reconstructed from work history and information on factory processes and exposures. Cox proportional hazards analysis was performed to estimate hazard ratios (HR) for reproductive factors and occupational exposures. RESULTS: Associations were observed between thyroid cancer and employment in jobs with 10 or more years of benzene exposure (HR 6.43, 95% CI: 1.08, 38) and formaldehyde exposure (HR 8.33, 95% CI: 1.16, 60). Administration workers also had an increased risk (HR 1.56, 95% CI: 1.08, 2.25). No associations between examined reproductive factors and thyroid cancer were observed in this study. CONCLUSIONS: Despite statistically imprecise risk estimates, the findings suggest potential associations with some occupational chemical exposures in this cohort of textile workers.
OBJECTIVES:Thyroid cancer risk has been previously associated with increased age at first pregnancy and history of miscarriage. Occupational risk factors for thyroid cancer, with the exception of radioactive iodine, have not been well investigated. We conducted a case-cohort study nested in a cohort of 267,400 female textile workers in Shanghai, China, who had been followed for cancer incidence during 1989-1998. METHODS: The analysis included 130 incident thyroid cases and 3,187 subcohort non-cases. Reproductive history was determined by questionnaire at baseline. Historical exposures were reconstructed from work history and information on factory processes and exposures. Cox proportional hazards analysis was performed to estimate hazard ratios (HR) for reproductive factors and occupational exposures. RESULTS: Associations were observed between thyroid cancer and employment in jobs with 10 or more years of benzene exposure (HR 6.43, 95% CI: 1.08, 38) and formaldehyde exposure (HR 8.33, 95% CI: 1.16, 60). Administration workers also had an increased risk (HR 1.56, 95% CI: 1.08, 2.25). No associations between examined reproductive factors and thyroid cancer were observed in this study. CONCLUSIONS: Despite statistically imprecise risk estimates, the findings suggest potential associations with some occupational chemical exposures in this cohort of textile workers.
Authors: L Dal Maso; C La Vecchia; S Franceschi; S Preston-Martin; E Ron; F Levi; W Mack; S D Mark; A McTiernan; L Kolonel; K Mabuchi; F Jin; G Wingren; M R Galanti; A Hallquist; E Glattre; E Lund; D Linos; E Negri Journal: Cancer Causes Control Date: 2000-02 Impact factor: 2.506
Authors: L Pagano; M Caputo; M T Samà; V Garbaccio; M Zavattaro; M G Mauri; F Prodam; P Marzullo; R Boldorini; G Valente; G Aimaretti Journal: Endocrine Date: 2012-10 Impact factor: 3.633
Authors: Virginia Lope; Beatriz Pérez-Gómez; Nuria Aragonés; Gonzalo López-Abente; Per Gustavsson; Nils Plato; Agustín Silva-Mato; Marina Pollán Journal: Int Arch Occup Environ Health Date: 2008-03-26 Impact factor: 3.015
Authors: L Zabuliene; D Jasilionis; E Miseikyte-Kaubriene; R Stukas; A Kaceniene; G Smailyte Journal: Horm Cancer Date: 2017-09-15 Impact factor: 3.869
Authors: Briseis Aschebrook-Kilfoy; Mary H Ward; Curt T Della Valle; Melissa C Friesen Journal: Occup Environ Med Date: 2014-03-06 Impact factor: 4.402