Literature DB >> 16220186

A formal synthesis of (+)-lactacystin.

Duncan J Wardrop1, Edward G Bowen.   

Abstract

A synthetic route to the neurotrophic agent (+)-lactacystin has been developed utilizing a base-promoted intramolecular alkylidenecarbene C-H insertion as the key transformation.

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Year:  2005        PMID： 16220186     DOI： 10.1039/b508300a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Highly diastereo- and enantioselective additions of homoenolates to nitrones catalyzed by N-heterocyclic carbenes.

Authors:  Eric M Phillips; Troy E Reynolds; Karl A Scheidt
Journal:  J Am Chem Soc       Date:  2008-01-31       Impact factor: 15.419

Review 2.  Neurotrophic natural products: chemistry and biology.

Authors:  Jing Xu; Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  Angew Chem Int Ed Engl       Date:  2013-12-18       Impact factor: 15.336

3.  Total Synthesis of (-)-Salinosporamide A via a Late Stage C-H Insertion.

Authors:  Hadi Gholami; Aman Kulshrestha; Olivia K Favor; Richard J Staples; Babak Borhan
Journal:  Angew Chem Int Ed Engl       Date:  2019-04-10       Impact factor: 15.336

4.  Dehydrative fragmentation of 5-hydroxyalkyl-1H-tetrazoles: a mild route to alkylidenecarbenes.

Authors:  Duncan J Wardrop; John P Komenda
Journal:  Org Lett       Date:  2012-02-28       Impact factor: 6.005

5.  Enantioselective synthesis of (+)-majusculone.

Authors:  Douglass F Taber; M Inthikhab Sikkander; Pierre H Storck
Journal:  J Org Chem       Date:  2007-04-21       Impact factor: 4.354
  5 in total

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