Literature DB >> 16219463

Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands.

Richard Chesworth1, Matthew D Wessel, Lisa Heyden, F Michael Mangano, Michael Zawistoski, Laura Gegnas, David Galluzzo, Bruce Lefker, Kimberly O Cameron, Jeanne Tickner, Bihong Lu, Tessa A Castleberry, Donna N Petersen, Amy Brault, Pia Perry, Oicheng Ng, Thomas A Owen, Lydia Pan, Hua-Zhu Ke, Thomas A Brown, David D Thompson, Paul DaSilva-Jardine.   

Abstract

A series of ligands with varying heterocyclic cores and substituents that display a range of selectivity's (up to >100x) for ER-beta over ER-alpha are reported.

Entities:  

Mesh:

Substances:

Year:  2005        PMID: 16219463     DOI: 10.1016/j.bmcl.2005.08.010

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Development of a recombinant human ovarian (BG1) cell line containing estrogen receptor α and β for improved detection of estrogenic/antiestrogenic chemicals.

Authors:  Jennifer C Brennan; Arzoo Bassal; Guochun He; Michael S Denison
Journal:  Environ Toxicol Chem       Date:  2015-12-09       Impact factor: 3.742

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.