| Literature DB >> 16219351 |
Xingpei Hao1, Min Sun Shin, Jeff X Zhou, Chang Hoon Lee, Chen Feng Qi, Zohreh Naghashfar, Janet W Hartley, Torgny N Fredrickson, Jerrold M Ward, Herbert C Morse.
Abstract
Six cases of megakaryocytic leukemia (MKL) were identified and analyzed for morphology and molecular features. MKL were composed of megakaryocyte lineage cells ranging from immature to quite mature cells. VWF, GATA1 and RUNX1 were strongly expressed in megakaryocytes in both normal spleen and MKL as analyzed by immunohistochemistry (IHC). Altered expression of Meis1, Pbx1 and Psen2 and Lef1 in MKL detected with oligonucleotide microarrays was confirmed by qPCR and IHC. This is the first report of spontaneous MKL in mice, defining VWF as a biomarker for diagnosis and suggesting possible involvement of a series of genes in disease pathogenesis.Entities:
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Year: 2005 PMID： 16219351 DOI： 10.1016/j.leukres.2005.08.021
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156