| Literature DB >> 16218607 |
Takuji Hatakeyama1, Shingo Ito, Masaharu Nakamura, Eiichi Nakamura.
Abstract
A magnesium enamide derived from N-2-(N',N'-diethylamino)ethyl imine reacts with a primary and secondary alkyl chloride or a primary alkyl fluoride to give an alpha-alkylated ketone in good to excellent yield after hydrolysis. The reaction takes place with a high level of inversion of stereochemistry at the electrophilic carbon center and will be useful for production of optically active compounds.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16218607 DOI： 10.1021/ja055306q
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419