| Literature DB >> 1621817 |
C O Watlington1, L B Kramer, E G Schuetz, J Zilai, W M Grogan, P Guzelian, F Gizek, A C Schoolwerth.
Abstract
Evidence for increased glucocorticoid 6 beta-hydroxylation (enhanced family 3A cytochrome P-450 activity) is found in certain reversible forms of human hypertension. This association was investigated in the spontaneously hypertensive rat (SHR). The proportion of injected [3H]corticosterone excreted in urine as 6 beta-[3H]OH-corticosterone was four- to fivefold higher in SHR than in control Wistar-Kyoto rats, before and after development of overt hypertension. Both hypertension and 6 beta-hydroxylation were inhibited by troleandomycin (a selective inhibitor of family 3A cytochromes P-450), consistent with a role for increased steroid 6 beta-hydroxylation in the genesis of hypertension in the SHR.Entities:
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Year: 1992 PMID： 1621817 DOI： 10.1152/ajprenal.1992.262.6.F927
Source DB: PubMed Journal: Am J Physiol ISSN： 0002-9513