OBJECTIVE: We sought to determine whether supplementation of vitamin E (alpha-tocopherol), selenium (L-selenomethionine), or their combination improves arsenical skin lesions. METHODS: A 2 x 2 randomized, placebo-controlled, double-blind trial among 121 men and women chronically exposed to arsenic in drinking water was conducted in rural Bangladesh. Participants were randomized to one of four treatment arms: vitamin E, selenium, vitamin E and selenium (combination), or placebo and were treated for 6 months. RESULTS: At baseline, the average skin lesion scores were 2.23, 2.26, and 2.63 and at follow-up, the average skin lesion scores went down to 2.00, 2.06, and 2.47 in those receiving vitamin E, selenium, and the combination, respectively. CONCLUSIONS: Supplementation with vitamin E and selenium, either alone or in combination, slightly improved skin lesion status, although the improvement was not statistically significant.
RCT Entities:
OBJECTIVE: We sought to determine whether supplementation of vitamin E (alpha-tocopherol), selenium (L-selenomethionine), or their combination improves arsenical skin lesions. METHODS: A 2 x 2 randomized, placebo-controlled, double-blind trial among 121 men and women chronically exposed to arsenic in drinking water was conducted in rural Bangladesh. Participants were randomized to one of four treatment arms: vitamin E, selenium, vitamin E and selenium (combination), or placebo and were treated for 6 months. RESULTS: At baseline, the average skin lesion scores were 2.23, 2.26, and 2.63 and at follow-up, the average skin lesion scores went down to 2.00, 2.06, and 2.47 in those receiving vitamin E, selenium, and the combination, respectively. CONCLUSIONS: Supplementation with vitamin E and selenium, either alone or in combination, slightly improved skin lesion status, although the improvement was not statistically significant.
Authors: Maria Argos; Mahfuzar Rahman; Faruque Parvez; James Dignam; Tariqul Islam; Iftekhar Quasem; Samar K Hore; Ahmed T Haider; Zahid Hossain; Tazul I Patwary; Muhammad Rakibuz-Zaman; Golam Sarwar; Paul La Porte; Judith Harjes; Kristen Anton; Muhammad G Kibriya; Farzana Jasmine; Rashed Khan; Mohammed Kamal; Christopher R Shea; Muhammad Yunus; John A Baron; Habibul Ahsan Journal: Eur J Clin Invest Date: 2013-04-17 Impact factor: 4.686
Authors: Brandon L Pierce; Lin Tong; Maria Argos; Jianjun Gao; Jasmine Farzana; Shantanu Roy; Rachelle Paul-Brutus; Ronald Rahaman; Muhammad Rakibuz-Zaman; Faruque Parvez; Alauddin Ahmed; Iftekhar Quasem; Samar K Hore; Shafiul Alam; Tariqul Islam; Judith Harjes; Golam Sarwar; Vesna Slavkovich; Mary V Gamble; Yu Chen; Mohammad Yunus; Mahfuzar Rahman; John A Baron; Joseph H Graziano; Habibul Ahsan Journal: Int J Epidemiol Date: 2013-12 Impact factor: 7.196
Authors: Goran Bjelakovic; Dimitrinka Nikolova; Lise Lotte Gluud; Rosa G Simonetti; Christian Gluud Journal: Cochrane Database Syst Rev Date: 2012-03-14
Authors: Wei Jie Seow; Wen-Chi Pan; Molly L Kile; Andrea A Baccarelli; Quazi Quamruzzaman; Mahmuder Rahman; Golam Mahiuddin; Golam Mostofa; Xihong Lin; David C Christiani Journal: Environ Health Perspect Date: 2012-10-10 Impact factor: 9.031