Literature DB >> 16216515

Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.

Yonghan Hu1, Jason S Xiang, Martin J DiGrandi, Xuemei Du, Manus Ipek, Leif M Laakso, Jianchang Li, Wei Li, Thomas S Rush, Jean Schmid, Jerauld S Skotnicki, Steve Tam, Jennifer R Thomason, Qin Wang, Jeremy I Levin.   

Abstract

Modification of alpha-biphenylsulfonamidocarboxylic acids led to potent and selective MMP-13 inhibitors. Compound 16 showed 100% oral bioavailability in rats and demonstrated >50% inhibition of bovine cartilage degradation at 10 ng/mL.

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Year:  2005        PMID： 16216515     DOI： 10.1016/j.bmc.2005.07.076

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  18 in total

Review 1.  Matrix metalloproteinase inhibitors: a critical appraisal of design principles and proposed therapeutic utility.

Authors:  György Dormán; Sándor Cseh; István Hajdú; László Barna; Dénes Kónya; Krisztina Kupai; László Kovács; Péter Ferdinandy
Journal:  Drugs       Date:  2010-05-28       Impact factor: 9.546

Review 2.  Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease.

Authors:  Mina M Benjamin; Raouf A Khalil
Journal:  Exp Suppl       Date:  2012

3.  A new approach to fused furan ring systems and benzofurans: Intramolecular cyclization reactions of unsaturated acyloxy sulfone derivatives.

Authors:  Yuan Liu; Hollie K Jacobs; Aravamudan S Gopalan
Journal:  Tetrahedron Lett       Date:  2011-06-08       Impact factor: 2.415

Review 4.  Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins.

Authors:  Arda Kucukguven; Raouf A Khalil
Journal:  Curr Drug Targets       Date:  2013-03       Impact factor: 3.465

Review 5.  Is there new hope for therapeutic matrix metalloproteinase inhibition?

Authors:  Roosmarijn E Vandenbroucke; Claude Libert
Journal:  Nat Rev Drug Discov       Date:  2014-11-07       Impact factor: 84.694

6.  Zymography as a Research Tool in the Study of Matrix Metalloproteinase Inhibitors.

Authors:  Zongli Ren; Juanjuan Chen; Raouf A Khalil
Journal:  Methods Mol Biol       Date:  2017

7.  Parallel synthesis of a multi-substituted benzo[b]furan library.

Authors:  Chul-Hee Cho; Benjamin Neuenswander; Gerald H Lushington; Richard C Larock
Journal:  J Comb Chem       Date:  2008-10-21

8.  In vitro-in vivo correlation on delivery of drug candidates to articular cartilage.

Authors:  Qin Wang; Sonya Glasson; Uma Raut; Jamie Emerson; Tracey Blanchet; Gary Bridson; Richard Sheldon; Nevena Mollova; Elisabeth Morris; Xin Xu; Vikram S Patel
Journal:  Pharm Res       Date:  2008-03-07       Impact factor: 4.200

9.  Synthesis of multi-functionalized benzofurans through the condensation of ninhydrin and phenols using SSA as a recyclable heterogeneous acid catalyst.

Authors:  Ashis Kundu; Animesh Pramanik
Journal:  Mol Divers       Date:  2016-02-01       Impact factor: 2.943

Review 10.  Physiology and pathophysiology of matrix metalloproteases.

Authors:  T Klein; R Bischoff
Journal:  Amino Acids       Date:  2010-07-18       Impact factor: 3.520
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