| Literature DB >> 16216508 |
Ashvinikumar V Gavai1, Roy J Vaz, Amarendra B Mikkilineni, Jacques Y Roberge, Yalei Liu, R Michael Lawrence, James R Corte, Wu Yang, Mark Bednarz, John K Dickson, Zhengping Ma, Ramakrishna Seethala, Jean H M Feyen.
Abstract
A 3D quantitative structure-activity relationship study for inhibition of calcium-sensing receptor in the aryloxypropanolamine series predicted that these molecules adopt a U-shaped conformation with pi-stacking between the two aromatic rings. This hypothesis led to the discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines capable of antagonizing the calcium-sensing receptor with potency comparable to that of NPS-2143.Entities:
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Year: 2005 PMID： 16216508 DOI： 10.1016/j.bmcl.2005.08.095
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823