Literature DB >> 16216502

Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors.

Irini Akritopoulou-Zanze1, Daria Darczak, Kathy Sarris, Kathleen M Phelan, Jeffrey R Huth, Danying Song, Eric F Johnson, Yong Jia, Stevan W Djuric.   

Abstract

We report the synthesis of kinase targeted libraries based on the thienopyrazole scaffold. Several thienopyrazole analogs have been identified as submicromolar inhibitors of KDR.

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Year:  2005        PMID： 16216502     DOI： 10.1016/j.bmcl.2005.09.042

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro.

Authors:  Jessica D Hess; Luca H Macias; Denisse A Gutierrez; Karla Moran-Santibanez; Lisett Contreras; Stephanie Medina; Paulina J Villanueva; Robert A Kirken; Armando Varela-Ramirez; Manuel L Penichet; Renato J Aguilera
Journal:  Biology (Basel)       Date:  2022-06-18

2.  Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality.

Authors:  Demetrio Raffa; Benedetta Maggio; Fabiana Plescia; Stella Cascioferro; Maria Valeria Raimondi; Gabriella Cancemi; Antonella D'Anneo; Marianna Lauricella; Maria Grazia Cusimano; Ruoli Bai; Ernest Hamel; Giuseppe Daidone
Journal:  Bioorg Med Chem       Date:  2015-08-28       Impact factor: 3.641
  2 in total

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