Literature DB >> 16215754

[The complement system and its possible role in the pathogenesis of age-related macular degeneration (AMD)].

P Charbel Issa1, H P N Scholl, F G Holz, P Knolle, C Kurts.   

Abstract

The discovery of the complement factor H (CFH) polymorphism in age-related macular degeneration (AMD) strongly suggests a causative role of the complement system in the pathogenesis of this disease. The complement system is part of the innate immune system and is closely associated with the cellular response and the adaptive immune system. This article provides an overview of the complement system and, taking the new data into account, of possible immunopathogenetic processes in AMD.

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Year:  2005        PMID： 16215754     DOI： 10.1007/s00347-005-1269-4

Source DB:  PubMed          Journal:  Ophthalmologe        ISSN： 0941-293X            Impact factor:   1.059


  20 in total

Review 1.  Risk factors for age-related macular degeneration.

Authors:  J R Evans
Journal:  Prog Retin Eye Res       Date:  2001-03       Impact factor: 21.198

2.  Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

Authors:  John W Crabb; Masaru Miyagi; Xiaorong Gu; Karen Shadrach; Karen A West; Hirokazu Sakaguchi; Motohiro Kamei; Azeem Hasan; Lin Yan; Mary E Rayborn; Robert G Salomon; Joe G Hollyfield
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-21       Impact factor: 11.205

3.  Complement factor H polymorphism in age-related macular degeneration.

Authors:  Robert J Klein; Caroline Zeiss; Emily Y Chew; Jen-Yue Tsai; Richard S Sackler; Chad Haynes; Alice K Henning; John Paul SanGiovanni; Shrikant M Mane; Susan T Mayne; Michael B Bracken; Frederick L Ferris; Jurg Ott; Colin Barnstable; Josephine Hoh
Journal:  Science       Date:  2005-03-10       Impact factor: 47.728

4.  Evidence for an inflammatory process in age-related macular degeneration gains new support.

Authors:  Dean Bok
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-10       Impact factor: 11.205

5.  Complement factor H polymorphism and age-related macular degeneration.

Authors:  Albert O Edwards; Robert Ritter; Kenneth J Abel; Alisa Manning; Carolien Panhuysen; Lindsay A Farrer
Journal:  Science       Date:  2005-03-10       Impact factor: 47.728

6.  Complement factor H variant increases the risk of age-related macular degeneration.

Authors:  Jonathan L Haines; Michael A Hauser; Silke Schmidt; William K Scott; Lana M Olson; Paul Gallins; Kylee L Spencer; Shu Ying Kwan; Maher Noureddine; John R Gilbert; Nathalie Schnetz-Boutaud; Anita Agarwal; Eric A Postel; Margaret A Pericak-Vance
Journal:  Science       Date:  2005-03-10       Impact factor: 47.728

7.  Candidate gene analysis suggests a role for fatty acid biosynthesis and regulation of the complement system in the etiology of age-related maculopathy.

Authors:  Yvette P Conley; Anbupalam Thalamuthu; Johanna Jakobsdottir; Daniel E Weeks; Tammy Mah; Robert E Ferrell; Michael B Gorin
Journal:  Hum Mol Genet       Date:  2005-06-01       Impact factor: 6.150

Review 8.  Complement factor H and hemolytic uremic syndrome.

Authors:  P F Zipfel; C Skerka; J Caprioli; T Manuelian; H H Neumann; M Noris; G Remuzzi
Journal:  Int Immunopharmacol       Date:  2001-03       Impact factor: 4.932

9.  A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration.

Authors:  Gregory S Hageman; Don H Anderson; Lincoln V Johnson; Lisa S Hancox; Andrew J Taiber; Lisa I Hardisty; Jill L Hageman; Heather A Stockman; James D Borchardt; Karen M Gehrs; Richard J H Smith; Giuliana Silvestri; Stephen R Russell; Caroline C W Klaver; Irene Barbazetto; Stanley Chang; Lawrence A Yannuzzi; Gaetano R Barile; John C Merriam; R Theodore Smith; Adam K Olsh; Julie Bergeron; Jana Zernant; Joanna E Merriam; Bert Gold; Michael Dean; Rando Allikmets
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-03       Impact factor: 11.205

Review 10.  A role for local inflammation in the formation of drusen in the aging eye.

Authors:  Don H Anderson; Robert F Mullins; Gregory S Hageman; Lincoln V Johnson
Journal:  Am J Ophthalmol       Date:  2002-09       Impact factor: 5.258
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  4 in total

Review 1.  [Intravitreal bevacizumab for neovascular age-related macular degeneration].

Authors:  M S Ladewig; F Ziemssen; G Jaissle; H-M Helb; H P N Scholl; N Eter; K U Bartz-Schmidt; F G Holz
Journal:  Ophthalmologe       Date:  2006-06       Impact factor: 1.059

Review 2.  [Therapy approaches for geographic atrophy].

Authors:  S Schmitz-Valckenberg; A Mössner; M Fleckenstein; P Wiedemann; F G Holz
Journal:  Ophthalmologe       Date:  2010-11       Impact factor: 1.059

3.  Characterization of human tear proteome reveals differentially abundance proteins in thyroid-associated ophthalmopathy.

Authors:  Xiaoqing Zhou; Ruili Wei; Rui Wang
Journal:  PeerJ       Date:  2022-07-12       Impact factor: 3.061

Review 4.  An update on the genetics of age-related macular degeneration.

Authors:  Hendrik P N Scholl; Monika Fleckenstein; Peter Charbel Issa; Claudia Keilhauer; Frank G Holz; Bernhard H F Weber
Journal:  Mol Vis       Date:  2007-02-07       Impact factor: 2.367
  4 in total

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